The Effect of Antibiotics and Drugs on the Duration of COVID-19 in Hospitalized Patients
- 25 October 2021
- journal article
- research article
- Published by Sciencedomain International in Journal of Pharmaceutical Research International
- Vol. 33 (47A), 49-58
- https://doi.org/10.9734/jpri/2021/v33i47a32988
Abstract
This is a single center, retrospective, observational study carried out in Ohud hospital, the main referral hospital for SARS-CoV-2 infections in the region of Madinah, Kingdom of Saudi Arabia. The study was carried on hospitalized patients with moderate to severe symptoms, including critically ill patients in the intensive care unit mostly of them requiring oxygen or mechanical ventilator support. Medical records from 432 cases were investigated showing that the majority of infected population were adults with an average age of 48 years, where 68.3% were males and the mortality rate was 5.6%. Duration of the disease was determined as the period between the first positive and the first negative PCR results. Patients who received antibiotics or Metoclopramide showed shorter duration of the disease time course while those who received Hydroxychloroquine, Omeprazole or Calcium exhibited longer durations before obtaining a negative PCR result. Regression analysis furtherly confirmed that antibiotics administration was associated with shorter course of disease while hydroxychloroquine or omeprazole were correlated with longer duration of the disease. Antiviral drugs, however, showed no correlations to the COVID-19 duration of stay in hospital. Finally, combining antibiotics and antiviral agents did not result in a better outcome, suggesting that the use of antibacterial agents helps in the recovery of SARS-CoV-2 patients.Keywords
This publication has 28 references indexed in Scilit:
- Proton pump inhibitors therapy and risk of Clostridium difficile infection: Systematic review and meta-analysisWorld Journal of Gastroenterology, 2017
- Pandemics, public health emergencies and antimicrobial resistance - putting the threat in an epidemiologic and risk analysis contextArchives of Public Health, 2017
- Pleiotropic Effects of Levofloxacin, Fluoroquinolone Antibiotics, against Influenza Virus-Induced Lung InjuryPLOS ONE, 2015
- Secondary Bacterial Infections in Influenza Virus Infection PathogenesisPublished by Springer Science and Business Media LLC ,2014
- Proton pump inhibitor therapy and potential long-term harmCurrent Opinion in Endocrinology, Diabetes and Obesity, 2014
- Immune Dysfunction and Bacterial Coinfections following InfluenzaThe Journal of Immunology, 2013
- Macrolides inhibit cytokine production by alveolar macrophages in bronchiolitis obliterans organizing pneumoniaImmunobiology, 2013
- MYC pathway activation in triple-negative breast cancer is synthetic lethal with CDK inhibitionThe Journal of Experimental Medicine, 2012
- Proton pump inhibitor-associated pneumonia: Not a breath of fresh air after all?World Journal of Gastrointestinal Pharmacology and Therapeutics, 2011
- How do viral infections predispose patients to bacterial infections?Current Opinion in Infectious Diseases, 2004