Positron emission tomography and magnetic resonance imaging: A review and a local circuit neurons hypo(dys)function hypothesis of schizophrenia
Abstract: A review of brain imaging (PET and MRI) studies on schizophrenia and recent data from neuroanatomy, neurophysiology, neuropathology, neurochemistry, neuropsychology, and cortical organization theory is integrated with the concept of local circuit neurons (LCNs) in a new hypothesis--the local circuit neurons hypo(dys)function hypothesis of schizophrenia--that attempts to explain the pathogenesis and pathophysiology of schizophrenia through a hypofunction (or dysfunction) of the local circuit neurons in prefrontal and limbic-temporal areas. This hypofunction (dysfunction) is then related to the neurocircuitry, neuropsychology, and psychopathology of schizophrenia.
Keywords: Dysfunction / Hypofunction / Local Circuit Neurons
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Click here to see the statistics on "Biological Psychiatry" .