Sildenafil citrate in healthy and diseased hearts
Open Access
- 16 April 2021
- journal article
- Published by Heighten Science Publications Corporation in Journal of Cardiology and Cardiovascular Medicine
- Vol. 6 (1), 033-039
- https://doi.org/10.29328/journal.jccm.1001115
Abstract
Sildenafil citrate is one of the frontline drugs used to manage erectile dysfunction (ED). Chemically, it is described as 1-[[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H –pyrazolo [4,3-d]pyrimidin-5-yl)-4 ethoxyphenyl] sulfonyl]-4-methylpiperazine citrate (C22H30N6O4 S). It is a highly selective inhibitor of cyclic guanine monophosphate-specific phosphodiesterase type-5. There had been heightened concerns following reports that sildenafil citrate may increase the risk of cardiovascular events, particularly fatal arrhythmias, in patients with cardiovascular disease. So the cardiac electrophysiological effects of sildenafil citrate have been investigated extensively in both animal and clinical studies. This article ties up the various outcomes of the investigations with a view to guiding physicians and patients that use sildenafil citrate to manage erectile dysfunction, especially as it concerns its effect on their cardiovascular function in health and in disease. Sildenafil citrate could impact negatively on ailing hearts, but on a healthy heart, there may not be any such impact, rather, it improves on heart performance as it lowers the blood pressure.Keywords
This publication has 42 references indexed in Scilit:
- cGMP-Dependent Protein Kinases and cGMP Phosphodiesterases in Nitric Oxide and cGMP ActionPharmacological Reviews, 2010
- Sildenafil Citrate Does Not Alter Ventricular Repolarization Properties: Novel Evidence from Dynamic QT AnalysisAnnals of Noninvasive Electrocardiology, 2004
- Protein kinase C plays an essential role in sildenafil-induced cardioprotection in rabbitsAmerican Journal of Physiology-Heart and Circulatory Physiology, 2004
- Treatment program for erectile dysfunction in patients with cardiovascular diseasesThe American Journal of Cardiology, 2004
- Sildenafil (Viagra) reduces arrhythmia severity during ischaemia 24 h after oral administration in dogsBritish Journal of Pharmacology, 2004
- Sildenafil citrate does not affect cardiac contractility in human or dog heartCurrent Medical Research and Opinion, 2003
- Second Consensus Conference on Cardiovascular Risk Factors and Erectile DysfunctionCurrent Medical Research and Opinion, 2002
- Management of sexual dysfunction in patients with cardiovascular disease: recommendations of the Princeton consensus panelThe American Journal of Cardiology, 2000
- Erectile DysfunctionThe New England Journal of Medicine, 2000
- Acute Myocardial Infarction after the Use of SildenafilThe New England Journal of Medicine, 1999