CXCL11 Signaling in the Tumor Microenvironment
- 22 July 2021
- book chapter
- research article
- Published by Springer Science and Business Media LLC
- Vol. 1302, 41-50
- https://doi.org/10.1007/978-3-030-62658-7_4
Abstract
CXCL11 which can bind to two different chemokine receptors, CXCR3 and CXCR7, has found a prominent place in current tumor research. In this chapter, we mainly discuss the current evidence on the role of the immune response of CXCL11 in tumor microenvironment (TME). The diverse functions of CXCL11 include inhibiting angiogenesis, affecting the proliferation of different cell types, playing a role in fibroblast directed carcinoma invasion, increasing adhesion properties, suppressing M2 macrophage polarization, and facilitating the migration of certain immune cells. In addition, we discussed the application of CXCL11 as an adjuvant to various mainstream anti-cancer therapies and the future challenges in the application of CXCL11 targeted therapies.Keywords
This publication has 46 references indexed in Scilit:
- Chemokine receptor trio: CXCR3, CXCR4 and CXCR7 crosstalk via CXCL11 and CXCL12Cytokine & Growth Factor Reviews, 2013
- Altered CXCR3 isoform expression regulates prostate cancer cell migration and invasionMolecular Cancer, 2012
- Expression and agonist responsiveness of CXCR3 variants in human T lymphocytesImmunology, 2011
- The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27Nature Immunology, 2010
- CXCR3/Ligands Are Significantly Involved in the Tumorigenesis of Basal Cell CarcinomasThe American Journal of Pathology, 2010
- CXCR7 Functions as a Scavenger for CXCL12 and CXCL11PLOS ONE, 2010
- Organ-specific inhibition of metastatic colon carcinoma by CXCR3 antagonismBritish Journal of Cancer, 2009
- CXCL10+ T cells and NK cells assist in the recruitment and activation of CXCR3+ and CXCL11+ leukocytes during Mycobacteria-enhanced colitisBMC Immunology, 2008
- Development of a novel chemokine-mediated in vivo T cell recruitment assayJournal of Immunological Methods, 2008
- A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor developmentThe Journal of Experimental Medicine, 2006