Changes in health-related quality of life in oesophagogastric cancer patients participating in palliative and curative therapies
Open Access
- 30 October 2018
- journal article
- Published by Academic World Research in Medical Journal of the Islamic Republic Of Iran
- Vol. 32 (1), 182-190
- https://doi.org/10.14196/mjiri.32.31
Abstract
Various treatments are used to prolong survival and improve quality of life (QOL). The purpose of this study was to assess the change in QOL scores in patients with Oesophagogastric (OG) cancer undergoing curative intent and palliative therapy. This was a mix-designed cohort study with a consecutive sampling of patients with OG cancer who underwent curative or palliative treatment regimens. The QOL, as a determinant of efficacy and impact of cancer care, was evaluated using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaires. QOL data were collected from the eligible subjects at three points of time. The repeated measurement test was used to compare the significance of change in scores. Overall, 149 patients (54.4% male, 61.1% curative intent, 52.3% esophageal, 37.6 % gastric, 10.1% OG junction cancer; with mean age 62 year) with OG cancer were eligible for inclusion in the study. Compared to the palliative group, the curative group was more likely to have an esophageal tumor site, Squamous Cell Carcinoma, and stage 2 (versus stomach, Adenocarcinoma, and stage 4 in the palliative group). In comparing the patients' functional, global health status, and cancer symptom, considering time, group of treatment, and their mutual effect the result indicated significant difference between the intervention groups. Most patients with Oesophagogastric cancer are diagnosed with an incurable form of the disease. Hence in absence of curative treatment, palliative therapy is the most effective therapy to maintain patient independency and relieve pain and symptom in order to improve their QOL. The present study has shown that palliative similar to curative intervention can improve the QOL in cancer patient especially in short term.Keywords
This publication has 50 references indexed in Scilit:
- Clinical significance of palliative gastrectomy on the survival of patients with incurable advanced gastric cancer: a systematic review and meta-analysisBMC Cancer, 2013
- Changes of Quality of Life after Gastric Cancer SurgeryJournal of Gastric Cancer, 2012
- 7th Edition of the AJCC Cancer Staging Manual: StomachAnnals of Surgical Oncology, 2010
- 7th Edition of the AJCC Cancer Staging Manual: Esophagus and Esophagogastric JunctionAnnals of Surgical Oncology, 2010
- Impact of chemotherapy on quality of life in patients with metastatic esophagogastric cancerCancer, 2010
- Advances in Measuring Quality-of-Life Outcomes in Cancer CareSeminars in Oncology Nursing, 2010
- Quality of life in patients with gastric cancer: translation and psychometric evaluation of the Iranian version of EORTC QLQ-STO22BMC Cancer, 2009
- Health-related quality of life in esophageal cancer: Effect of neoadjuvant chemoradiotherapy followed by surgical interventionThe Journal of Thoracic and Cardiovascular Surgery, 2009
- Long-term health-related quality of life following surgery for oesophageal cancerBritish Journal of Surgery, 2008
- Clinical and psychometric validation of a questionnaire module, the EORTC QLQ-OG25, to assess health-related quality of life in patients with cancer of the oesophagus, the oesophago–gastric junction and the stomachEuropean Journal of Cancer, 2007