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Efficacy and Safety of Landiolol in Patients With Ventricular Tachyarrhythmias With or Without Renal Impairment ― Subanalysis of the J-Land II Study ―

Tsuyoshi Shiga, Takanori Ikeda, Wataru Shimizu, Koichiro Kinugawa, Atsuhiro Sakamoto, Ryozo Nagai, Takashi Daimon, Kaori Oki, Haruka Okamoto, Takeshi Yamashita
Published: 7 August 2020
Circulation Reports , Volume 2, pp 440-445; doi:10.1253/circrep.cr-20-0017

Abstract: Background:Post hoc analysis was used to investigate the effects of renal function on the efficacy and safety of landiolol using data from the J-Land II study, which evaluated landiolol in patients with hemodynamically unstable ventricular tachycardia (VT) or ventricular fibrillation (VF) who were refractory to Class III antiarrhythmic drugs. Methods and Results:Patient data from the J-Land II study (n=29) were stratified by renal function (estimated glomerular filtration rate [eGFR]
Keywords: Efficacy / Renal function / proportion / Ml/min/1.73 / Safety of Landiolol / μg/kg/min

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