Objective: To evaluate and define a plant extract for the control of the yellow aphid in order to prevent environmental contamination and improve crop profitability. Design/Methodology/Approach: In a sorghum plot —located in the municipality of Jantetelco, Morelos— with a high incidence of yellow aphids, three doses —2-, 4-, and 6-mL L-1 of water of Quillaja saponaria extract, 0.2-mL L-1 of water of Imidacloprid, and 10-mL L-1 of water of calcium polysulfide—, as well as an absolute control, were evaluated. The applications were carried out using a 15-L manual spray backpack, which had been previously calibrated and had a fan nozzle. A randomized block experimental design—with six treatments and four repetitions— was used. The experimental unit was made up of five 5-m long rows with 0.70 m between rows, resulting in a 17.5 m2 total area per experimental unit. The three central furrows were the useful plot, leaving 0.5 m at each end of the furrow. The total size of the experimental plot was 420 m2. Results: The biological effectiveness during the samplings was as follows: both the Quillaja saponaria (6-, 4- and 2-mL L-1 water doses) and Imidacloprid treatments had a 100% effectiveness. Study limitations/implications: This study was carried out in sorghum crops. Findings/conclusions: Treatments based on Quillaja saponaria extracts on M. sacchari in sorghum crops showed 100% biological effectiveness from the first application and no phytotoxicity was observed in any treatment