Comparative analysis of prothrombotic activity in patients with myocardial infarction with and without obstructive coronary artery disease
Open Access
- 28 March 2021
- journal article
- Published by Silicea - Poligraf, LLC in Russian Journal of Cardiology
- Vol. 26 (2), 3939
- https://doi.org/10.15829/1560-4071-2021-3939
Abstract
Aim.To compare parameters of prothrombotic activity in patients with myocardial infarction (MI) with obstructive (MICAD) and non-obstructive coronary artery disease (MINOCA).Material and methods.The study included 40 patients with MI, which were divided into experimental (n=19) and control group (n=21). Three patients (15,7%) with acute myocarditis were excluded from the analysis. Hemostasiological and hematological blood tests were studied upon admission, on the 2nd, 4th, 7th days from hospitalization. Blood samples for protein C, antithrombin, von Willebrand factor (VWF), plasminogen, homocysteine were performed on 4th±1 day from hospitalization. To determine the IgG/IgM anticardiolipin (aCL) and anti-beta 2 glycoprotein I (β2-GPI) antibodies in order to diagnose antiphospholipid syndrome (APS), the ORGENTEC Anti- β2-Glycoprotein I IgG/IgM ELISA enzyme immunoassay was used. Blood tests for lupus anticoagulant were performed using an ACL-Top 700 analyzer (Werfen) with HemosIL SynthASil dRVVT screen/dRVVT confirm and with a SCT screen/SCT confirm quartz activator.Results.According to the data obtained, it was found that patients with MINOCA had a significantly lower level of plasminogen (p=0,007), as well as a higher level of homocysteine (p=0,03). For such indicators as protein C, antithrombin, ejection fraction, differences between the groups were not revealed (p0,05). There was a higher platelet count in patients with MINOCA on the 2ndand 4thdays of acute MI (p=0,46 and p=0,01, respectively). However, the hemoglobin level in patients with MINOCA was significantly lower on admission, 4thand 7thday of MI (p=0,02, p=0,03 and p=0,04, respectively).Conclusion.According to the study results, in patients with MINOCA and MICAD, differences in blood thrombotic activity were revealed. A higher level of homocysteine and a lower level of plasminogen were determined in patients with MINOCA. For such parameters as protein C, antithrombin, VWF, aCL and β2-GPI antibodies, differences between the groups were not determined. According to laboratory data, patients with MINOCA showed higher platelet count, but lower levels of hemoglobin and hematocrit in the early postinfarction period.Keywords
This publication has 20 references indexed in Scilit:
- Kinetics of plasma von Willebrand factor in acute myocardial infarction patients: a meta-analysisOncotarget, 2017
- Acute myocardial infarction and antiphospholipid antibody syndromeCoronary Artery Disease, 2017
- Correlation Between Hyperhomocysteinemia and Outcomes of Patients With Acute Myocardial InfarctionClinical Journal of Sport Medicine, 2016
- The problem of thrombophilia in clinical practiceRussian Journal of Children Hematology and Oncology, 2015
- Systematic Review of Patients Presenting With Suspected Myocardial Infarction and Nonobstructive Coronary ArteriesJournal of the American College of Cardiology, 2015
- Prevalence of Hyperhomocysteinemia in China: A Systematic Review and Meta-AnalysisNutrients, 2014
- Antithrombin Cambridge II (A384S) supports a role for antithrombin deficiency in arterial thrombosisThrombosis and Haemostasis, 2009
- Arterial Thrombosis and the Role of ThrombophiliaSeminars in Thrombosis and Hemostasis, 2007
- Long term prognosis of patients with myocardial infarction and normal coronary angiography: impact of inherited coagulation disordersThrombosis and Haemostasis, 2004
- New Markers of Inflammation and Endothelial Cell ActivationJournal of the American College of Cardiology, 2003