Positional Information and Stem Cells Combine to Result in Planarian Regeneration
- 13 September 2021
- journal article
- research article
- Published by Cold Spring Harbor Laboratory in Cold Spring Harbor Perspectives in Biology
- Vol. 14 (4), a040717
- https://doi.org/10.1101/cshperspect.a040717
Abstract
The capacity for regeneration is broad in the animal kingdom. Planarians are flatworms that can regenerate any missing body part and their regenerative powers have combined with ease of experimentation to make them a classic regeneration model for more than a century. Pluripotent stem cells called neoblasts generate missing planarian tissues. Fate specification happens in the neoblasts, and this can occur in response to regeneration instructions in the form of positional information. Fate specification can lead to differentiating cells in single steps rather than requiring a long lineage hierarchy. Planarians display constitutive expression of positional information from muscle cells, which is required for patterned maintenance of tissues in tissue turnover. Amputation leads to the rapid resetting of positional information in a process triggered by wound signaling and the resetting of positional information is required for regeneration. These findings suggest a model for planarian regeneration in which adult positional information resets after injury to regulate stem cells to bring about the replacement of missing parts.This publication has 162 references indexed in Scilit:
- Transcriptome Analysis of the Planarian Eye Identifies ovo as a Specific Regulator of Eye RegenerationCell Reports, 2012
- Genetic Regulators of a Pluripotent Adult Stem Cell System in Planarians Identified by RNAi and Clonal AnalysisCell Stem Cell, 2012
- Fate Restriction in the Growing and Regenerating Zebrafish FinDevelopmental Cell, 2011
- Cell death and tissue remodeling in planarian regenerationDevelopmental Biology, 2010
- Wnt Signaling and the Polarity of the Primary Body AxisCell, 2009
- Spoltud-1 is a chromatoid body component required for planarian long-term stem cell self-renewalDevelopmental Biology, 2009
- Molecular Analysis of Stem Cells and Their Descendants during Cell Turnover and Regeneration in the Planarian Schmidtea mediterraneaCell Stem Cell, 2008
- A bruno-like Gene Is Required for Stem Cell Maintenance in PlanariansDevelopmental Cell, 2006
- Allometric scaling and proportion regulation in the freshwater planarian Schmidtea mediterraneaDevelopmental Dynamics, 2003
- Expression ofvasa(vas)-Related Genes in Germline Cells and Totipotent Somatic Stem Cells of PlanariansDevelopmental Biology, 1999