Organism involved and clinical presentation in proven neonatal sepsis affecting platelet indices

Abstract

Background: Sepsis is a common complication in the neonatal intensive care unit and is a major cause of neonatal mortality. Objective: To identify organism involved in proven neonatal sepsis affecting platelet indices. Setting: The study was carried out over a period of one and half year from December 2015 to July 2017 at Sangmeshwar and Basaveshwar Hospital attached to M.R. Medical College, KALABURAGI. 100 cases were considered for this study after proper screening for CBC, platelet count and their indices like mean platelet volume, platelet distribution width and CRP and blood culture in neonates admitted in our NICU with proven sepsis.Result: A total of 100 neonates with blood culture positive for bacterial cases were considered for the study. Early onset septicaemia (59%) was more common than late onset septicaemia (41%). Out of 100 cases 57% cases had growth of gram negative organisms, 40% had growth of gram positive organisms and 3% had growth of fungal. Tachypnea (27%), Lethargy (20%) and refusal of feeds (8%) were the commonest clinical presentation followed by, Fever (6%), convulsions (5%) and jaundice (5%). 60% neonates had thrombocytopenia of varying severity. Staphylococcus aureus was the most common organism associated with thrombocytopenia (43.3%). Conclusion: It was concluded that neonatal sepsis was common in males. Gram positive organisms were the predominant causative agents of septicaemia 40% as compared to gram negative organisms 57% and fungal sepsis 3%. Staphylococcus aureus was the commonest organism responsible for thrombocytopenia.