A Promising Strategy for Non-Arteritic Anterior Ischemic Optic Neuropathy: Intravitreal Mesenchymal Stem Cell Exosome
- 12 February 2021
- journal article
- research article
- Published by Bentham Science Publishers Ltd. in Current Stem Cell Research & Therapy
- Vol. 16 (2), 109-114
- https://doi.org/10.2174/1574888x15666200814121849
Abstract
Non-arteritic anterior ischemic optic neuropathy (NAION) is a leading cause of optic nerve-related permanent visual impairment among individuals of over 50 years of age after glaucoma. Because of perplexing disorder regarding its pathogenesis, there is still no widely accepted and established treatment plan. Mesenchymal stem cells (MSCs) are one of the rare stem cell types that therapeutic agents for immunomodulation and ischemic tissue repair in clinical practice. However, there are certain disadvantages in using MSCs, such as potential tumorigenicity, need for autologous collection, and short survival time. Previous evidence suggested that MSC-exosomes significantly attenuated post-ischemic neuronal damage and induced long-term neuroprotection associated with enhanced angiogenesis in MSCs.Keywords
Funding Information
- Clinical Research Innovation Plan of Shanghai General Hospital (CTCCR-2018BP04)
- Shanghai Science and Technology Commission Research Project (19401932700)
- National Science and Technology Major Project of China (2017ZX09304010)
- National Key R&D Program of China (2016YFC0904800, 2019YFC0840607)
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