Long-term results of treatment for patients with locally advanced external ear skin cancer
Open Access
- 24 April 2021
- journal article
- Published by Publishing House ABV Press in Head and Neck Tumors (HNT)
- Vol. 11 (1), 12-23
- https://doi.org/10.17650/2222-1468-2021-11-1-12-23
Abstract
The study objective is to assess long-term results of treatment for patients with locally advanced external ear skin cancer.Materials and methods. This research work based on a retrospective and prospective analysis case history for patients with locally advanced external ear skin cancer. These are 45 patients, who received treatment in surgical department of head and neck tumors in Blokhin National Medical Research Center of Oncology between 1994 and 2020. Patient observation time averaged 30.0 ± 32.3 months (from 0.7 to 117.4 months, median 12.0 months). We divided patients into 3 groups depending on treatment methods. Group 1 consisted of patients who received combined or complex treatment (33.3 %, n = 15). Treatment for first group patients involved subtotal, lateral temporal bone resection or incomplete lateral resection and postoperative radiation therapy on the area of primary tumor and regional metastasis zone (total focal dose from 60 Gy). In the case of complex treatment, radiation therapy had carried out against background cisplatin introduction. The second group consisted of patients who received only surgical treatment (40.0 %, n = 18). Temporal bone resections were not performed for patients of the third group (26.7 %, n = 12). Treatment for patients of the third group involved one of the treatment methods: cryodestruction, laser destruction, photodynamic therapy, radiotherapy or chemoradiation treatment.Results. Five-year survival without signs of progression in a group of patients with locally advanced of the ear skin cancer, who received combined or complex treatment was 73.8 ± 13.1. Median progression-free survival not achieved. In the surgical treatment group 5 year progression-free survival was 40.4 ± 13.0, median was 34.1 months. In a group of patients who did not undergo temporal bone resection (3rd group) median progression-free survival was 4.5 months. Group differences are statistically significant (p Conclusion. Combined/complex treatment of patients with locally advanced ear skin cancer (surgery with postoperative radiotherapy/chemoradiotherapy) provides better long-term results compared to other treatment options.Keywords
This publication has 19 references indexed in Scilit:
- Squamous cell carcinoma of the temporal bone: A current reviewLaryngoscope Investigative Otolaryngology, 2019
- Multiple primary metachronous cancer of the ear (a case report)Vestnik otorinolaringologii, 2016
- Survival Outcomes in Surgical Treatment of 72 Cases of Squamous Cell Carcinoma of the Temporal BoneOtology & Neurotology, 2011
- The Outcome of Radical Surgery and Postoperative Radiotherapy for Squamous Carcinoma of the Temporal BoneThe Laryngoscope, 2005
- Extended Temporal Bone Resection for Squamous Cell CarcinomaOtolaryngology -- Head and Neck Surgery, 1997
- Efficacy of surgical treatments for squamous cell carcinoma of the temporal bone: A literature reviewOtolaryngology -- Head and Neck Surgery, 1994
- Malignancies of the external ear canal and temporal bone: Surgical techniques and resultsThe Laryngoscope, 1987
- Total en bloc resection of the temporal bone and carotid artery for malignant tumors of the ear and temporal boneThe Laryngoscope, 1984
- The Surgical Treatment of Malignant Tumors of the Ear and Temporal Bone: Part IJAMA Otolaryngology–Head & Neck Surgery, 1960
- Subtotal resection of the temporal bone for cancer of the earCancer, 1954