Sesamin Attenuates Obesity-Associated Nonalcoholic Steatohepatitis in High-Fat and High-Fructose Diet-Fed Mice
- 1 March 2023
- journal article
- research article
- Published by Mary Ann Liebert Inc in Journal of Medicinal Food
- Vol. 26 (3), 176-184
- https://doi.org/10.1089/jmf.2022.k.0091
Abstract
This study explored the effects of sesamin on nonalcoholic steatohepatitis (NASH). High-fat and high-fructose diet-fed mice supplemented with or without sesamin. The results suggested that sesamin-treated mice lost body weight and fat tissue weight, had lower levels of serum metabolic parameters, and insulin resistance was mitigated. Histological examinations showed that sesamin treatment mitigated the progression of hepatic steatosis, and inflammation. In addition, sesamin enhanced hepatic antioxidant capacity, and decreased the activations of hepatic c-jun N-terminal kinase, inhibitor of kappa B kinase α, and insulin receptor substrate 1 as well as hepatic interleukin-6 and tumor necrosis factor-alpha levels. Further experiments indicated that sesamin treatment downregulated GRP78 and phospho-inositol-requiring enzyme 1 (IRE1) expression, and upregulated x-box binding protein 1 (XBP1) expression in hepatic tissue. The aforementioned results suggest that sesamin alleviates obesity-associated NASH, which might be linked to the effect of sesamin on the regulation of the hepatic endoplasmic reticulum stress-IRE1/XBP1 pathway. Thus, sesamin may be a good food functional ingredient in the treatment of obesity-associated NASH.Keywords
This publication has 37 references indexed in Scilit:
- Histopathological algorithm and scoring system for evaluation of liver lesions in morbidly obese patientsJournal of Hepatology, 2012
- Sesamin attenuates intercellular cell adhesion molecule‐1 expression in vitro in TNF‐α‐treated human aortic endothelial cells and in vivo in apolipoprotein‐E‐deficient miceMolecular Nutrition & Food Research, 2010
- Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic DiseaseCell, 2010
- Endoplasmic Reticulum StressAnnals of the New York Academy of Sciences, 2007
- Autocrine Tumor Necrosis Factor Alpha Links Endoplasmic Reticulum Stress to the Membrane Death Receptor Pathway through IRE1α-Mediated NF-κB Activation and Down-Regulation of TRAF2 ExpressionMolecular and Cellular Biology, 2006
- Mechanisms of Liver Injury. I. TNF-α-induced liver injury: role of IKK, JNK, and ROS pathwaysAmerican Journal of Physiology-Gastrointestinal and Liver Physiology, 2006
- Insulin resistance, adiponectin, cytokines in NASH: Which is the best target to treat?Journal of Hepatology, 2006
- Nonalcoholic Fatty Liver Disease: From Steatosis to CirrhosisJournal of Hepatology, 2006
- Contrasting Effects of IRS-1 Versus IRS-2 Gene Disruption on Carbohydrate and Lipid Metabolism in VivoOnline Journal of Public Health Informatics, 2000
- Analysis of serial measurements in medical research.BMJ, 1990