Efficacy of tranexamic acid in decreasing primary hemorrhage in transurethral resection of the prostate: A novel combination of intravenous and topical approach
Open Access
- 1 January 2021
- journal article
- research article
- Published by Medknow in Urology Annals
- Vol. 13 (3), 238-242
- https://doi.org/10.4103/ua.ua_41_20
Abstract
Background: Transurethral resection of the prostate (TURP) is the gold standard for benign prostatic enlargement; however, hemorrhage still remains one of the major complications. Objective: The primary aim of this study was to evaluate the effect of tranexamic acid (TXA) in reducing intraoperative blood loss and need for blood transfusion. Secondary parameters compared were operating time, volume of irrigation fluid used, and reduction in hemoglobin concentration. Subjects and Methods: A total of 70 eligible patients undergoing TURP were randomized based on computer generated table into two groups. The study group (1) received IV TXA 500 mg after induction of anesthesia and 500 mg in each irrigation fluid bottle (dual mode) and the control group (2) received none. Results: The mean age (68.20 vs. 66.5 years), prostate size (57 vs. 51 g), and preoperative hemoglobin (13.3 vs. 13.5 g/dl) were similar between the groups. Intraoperative blood loss in the TXA group was found to be significantly reduced (174.60 ± 125.38 ml vs. 232.47 ± 116.8; P = 0.04). Blood transfusion was required in 2.8% of cases as compared to 14.2% in controls. Operating time, volume of irrigation fluid, and postoperative reduction of hemoglobin were not significant between the groups. No complications were observed in both groups. Conclusion: In this study, we observed that TXA, when used as a combination of Intravenous and topical route, effectively reduced intra-operative blood loss and the need for transfusion.Keywords
This publication has 20 references indexed in Scilit:
- Antifibrinolytic agents in current anaesthetic practiceBritish Journal of Anaesthesia, 2013
- Tranexamic AcidDrugs, 2012
- Etiology, Epidemiology, and Natural HistoryUrologic Clinics of North America, 2009
- Can local application of Tranexamic acid reduce post-coronary bypass surgery blood loss? A randomized controlled trialJournal of Cardiothoracic Surgery, 2009
- Fibrinolysis or hypercoagulation during radical prostatectomy? An evaluation of thrombelastographic parameters and standard laboratory testsEuropean Journal of Anaesthesiology, 2008
- Complications of Transurethral Resection of the Prostate (TURP)—Incidence, Management, and PreventionEuropean Urology, 2006
- Do Antifibrinolytics Reduce Allogeneic Blood Transfusion in Orthopedic Surgery?Anesthesiology, 2006
- Tranexamic acid in control of primary hemorrhage during transurethral prostatectomyUrology, 2004
- Is tranexamic acid safe in patients undergoing coronary endarterectomy?The Annals of Thoracic Surgery, 2001
- Hemostatic Effect of Tranexamic Acid Mouthwash in Anticoagulant-Treated Patients Undergoing Oral SurgeryThe New England Journal of Medicine, 1989