Background: Increased rate of water pollution has detrimental effects on the health of fish and other aquatic organisms. This invariably affects humans by causing food insecurity, hunger and poverty. In an effort to curb this menace, this study investigated the effects of crude tuber peel extract of Tacca leontopetaliodes on the biochemical and histological parameters of Clarias gariepinus. Methods: Acute toxicity (96 hr . LC50) test was conducted after a range finding test from which definitive test concentrations of 5.00, 4.00, 3.00, 2.00, and 1.00 g/L were obtained with 0.00 g/L as control. One hundred and twenty (120) mixed sex C. gariepinus fingerlings (mean weight, 12.5 g ± 0.5; length, 13.2 cm ± 0.5) were administered definitive concentrations of crude tuber peel extract in duplicate replication. Water quality parameters (pH, dissolved oxygen, free carbon dioxide, alkalinity), tissue enzymes (Alkaline phosphatase (ALP), Alanine Aminotransferase (ALT), Aspartate Aminotransferase (AST) and histopathological assessments were analysed using standard procedures. Results: Physico-chemical parameters (pH, dissolved oxygen, free carbon dioxide and alkalinity) of test tanks containing graded concentrations of T. leontopetaliodes were significantly altered (p