Docking of Indolizine Derivatives on Cube Rhombellane Functionalized Homeomorphs
- 3 August 2018
- journal article
- research article
- Published by Babes-Bolyai University in Studia Universitatis Babeș-Bolyai Chemia
- Vol. 63 (2), 7-18
- https://doi.org/10.24193/subbchem.2018.2.01
Abstract
Indolizines represent a class of heteroaromatic compounds (of pharmacological importance) containing two condensed (5- and 6-memebered) rings bridged by a nitrogen atom, showing a variety of biological activities. An attempt was made to deposit indolizines on the cube rhombellane homeomorphs surface as possible nano-drug complexes, since rhombellane homeomorphs may be bound in a protein as the active pocket and further may be used in personalized medicine. In the present study, a molecular docking analysis of two indolizine derivatives on some cube rhombellane homeomorphs was carried out for the first time.Keywords
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