Single-cell analysis of olfactory neurogenesis and differentiation in adult humans
Top Cited Papers
- 17 February 2020
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature Neuroscience
- Vol. 23 (3), 323-326
- https://doi.org/10.1038/s41593-020-0587-9
Abstract
The presence of active neurogenic niches in adult humans is controversial. We focused attention to the human olfactory neuroepithelium, an extracranial site supplying input to the olfactory bulbs of the brain. Using single-cell RNA sequencing analyzing 28,726 cells, we identified neural stem cell and neural progenitor cell pools and neurons. Additionally, we detailed the expression of 140 olfactory receptors. These data from the olfactory neuroepithelium niche provide evidence that neuron production may continue for decades in humans.Keywords
Funding Information
- U.S. Department of Health & Human Services | NIH | NCI | Division of Cancer Epidemiology and Genetics, National Cancer Institute (CA125970)
- U.S. Department of Health & Human Services | NIH | National Institute on Deafness and Other Communication Disorders (DC013556, DC016859)
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