Resistin is a risk factor for all-cause mortality in elderly Finnish population: A prospective study in the OPERA cohort
Open Access
- 2 March 2021
- journal article
- research article
- Published by Public Library of Science (PLoS) in PLOS ONE
- Vol. 16 (3), e0248015
- https://doi.org/10.1371/journal.pone.0248015
Abstract
Objective Resistin is a small, cysteine-rich proinflammatory molecule that is primarily secreted by peripheral blood mononuclear cells and macrophages in humans. Previous studies have shown resistin to participate in various pathological processes including atherosclerosis and cancer progression but not many studies have assessed the role of resistin as a risk factor for all-cause mortality. The objective of this prospective study was to evaluate whether resistin predicts mortality among elderly Finnish people. Methods The study population consisted of 599 elderly (71.7 ± 5.4 years) patients and the follow-up was approximately six years. A thorough clinical examination including anthropometric and other clinical measurements such as blood pressure as well as various laboratory parameters (including resistin) was conducted at baseline. Results After the follow-up, 65 (11%) of the patients died. Resistin was a significant risk factor for all-cause mortality (HR 3.02, 95% CI: 1.64–5.56, p Conclusions Our results indicate that resistin is a significant risk factor for all-cause mortality among elderly Finnish subjects, independent from traditional cardiovascular risk factors.Keywords
This publication has 32 references indexed in Scilit:
- Resistin: A reappraisalMechanisms of Ageing and Development, 2019
- Resistin’s, obesity and insulin resistance: the continuing disconnect between rodents and humansJournal of Endocrinological Investigation, 2015
- Association between resistin levels and cardiovascular disease events in older adults: The health, aging and body composition studyAtherosclerosis, 2015
- Serum Resistin Concentrations and Risk of New Onset Heart Failure in Older PersonsArteriosclerosis, Thrombosis, and Vascular Biology, 2009
- High Plasma Resistin Level Is Associated with Enhanced Highly Sensitive C-Reactive Protein and LeukocytesJournal of Clinical Endocrinology & Metabolism, 2006
- Resistin, an Adipokine with Potent Proinflammatory PropertiesThe Journal of Immunology, 2005
- An Inflammatory Cascade Leading to Hyperresistinemia in HumansPLoS Medicine, 2004
- Resistin Promotes Smooth Muscle Cell Proliferation Through Activation of Extracellular Signal–Regulated Kinase 1/2 and Phosphatidylinositol 3-Kinase PathwaysJournal of the American College of Cardiology, 2004
- Resistin is expressed in human macrophages and directly regulated by PPARγ activatorsBiochemical and Biophysical Research Communications, 2003
- A family of tissue-specific resistin-like moleculesProceedings of the National Academy of Sciences of the United States of America, 2001