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Resistin is a risk factor for all-cause mortality in elderly Finnish population: A prospective study in the OPERA cohort

Karri Parkkila, , Mikko Tulppo, Juha Perkiömäki, Y. Antero Kesäniemi,
Published: 2 March 2021
PLoS ONE , Volume 16; doi:10.1371/journal.pone.0248015

Abstract: Objective Resistin is a small, cysteine-rich proinflammatory molecule that is primarily secreted by peripheral blood mononuclear cells and macrophages in humans. Previous studies have shown resistin to participate in various pathological processes including atherosclerosis and cancer progression but not many studies have assessed the role of resistin as a risk factor for all-cause mortality. The objective of this prospective study was to evaluate whether resistin predicts mortality among elderly Finnish people. Methods The study population consisted of 599 elderly (71.7 ± 5.4 years) patients and the follow-up was approximately six years. A thorough clinical examination including anthropometric and other clinical measurements such as blood pressure as well as various laboratory parameters (including resistin) was conducted at baseline. Results After the follow-up, 65 (11%) of the patients died. Resistin was a significant risk factor for all-cause mortality (HR 3.02, 95% CI: 1.64–5.56, p Conclusions Our results indicate that resistin is a significant risk factor for all-cause mortality among elderly Finnish subjects, independent from traditional cardiovascular risk factors.
Keywords: Physical activity / Resistin / Inflammation / Blood pressure / Cancer risk factors / Geriatric care / Alcohol consumption / Cardiovascular disease risk

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