Vitamin D status and pulmonary exacerbations in children and adolescents with cystic fibrosis: Experience from a tertiary care center
Open Access
- 1 January 2021
- journal article
- research article
- Published by Medknow in Lung India
- Vol. 38 (4), 326-329
- https://doi.org/10.4103/lungindia.lungindia_589_20
Abstract
Background: The function of Vitamin D in preventing inflammation and infection has been studied previously for different pathologies in different populations globally. Relationships between serum Vitamin D levels and its effect on pulmonary exacerbations in the cystic fibrosis (CF) population are not well studied in our part of the world. Therefore, we aimed to ascertain the Vitamin D status in pediatric and adolescent CF patients and its association with pulmonary exacerbations. Materials and Methods: A retrospective study was conducted at The Aga Khan University Hospital from 2015 to 2018. Patients of CF with sweat chloride value >60 mmol/l and who had at least one measurement of 25 hydroxy Vitamin D (25 OHD) were included in the study. Annual serum Vitamin D levels were documented for enrolled patients and their past 1-year data were analyzed for pulmonary exacerbations, average length of stay, and tracheal/airway colonization with organisms. Results: 69 patients were included in the study. 28 patients (40.57%) were found to be Vitamin D deficient, 22 patients (31.88%) were Vitamin D insufficient and 19 patients (27.53%) were labeled as Vitamin D insufficient. The average number of exacerbations per year was significantly high in Vitamin D deficient group (3.71 ± 0.96) in comparison with insufficient (3.18 ± 1.09) and sufficient groups (2.26 ± 0.93) (P < 0.001). Conclusion: Vitamin D deficiency is related to an increased number of annual pulmonary exacerbations and pseudomonas infections.Keywords
This publication has 20 references indexed in Scilit:
- Vitamin D status correlates with the markers of cystic fibrosis-related pulmonary diseasePediatrics & Neonatology, 2019
- Vitamin D inhibits pro-inflammatory cytokines in the airways of cystic fibrosis patients infected by Pseudomonas aeruginosa- pilot studyItalian Journal of Pediatrics, 2019
- Epidemiology, Biology, and Impact of Clonal Pseudomonas aeruginosa Infections in Cystic FibrosisClinical Microbiology Reviews, 2018
- Vitamin D increases the antiviral activity of bronchial epithelial cells in vitroAntiviral Research, 2017
- Cystic fibrosis lung environment and Pseudomonas aeruginosa infectionBMC Pulmonary Medicine, 2016
- Poor Vitamin D Status in Healthy Populations in India: A Review of Current EvidenceInternational Journal for Vitamin and Nutrition Research, 2015
- Association between serum 25-hydroxyvitamin D level and pulmonary exacerbations in cystic fibrosisPediatric Pulmonology, 2015
- Evaluation of micronutrient profile of North Indian children with cystic fibrosis: a case–control studyPediatric Research, 2014
- Vitamin D Status in Children with Cystic Fibrosis. Associations with Inflammation and Bacterial ColonizationAnnals of the American Thoracic Society, 2014
- Vitamin D Deficiency Is Associated with Pulmonary Exacerbations in Children with Cystic FibrosisAnnals of the American Thoracic Society, 2014