Maternal Docosahexaenoic Acid Supplementation and Bronchopulmonary Dysplasia in Infants—Reply
- 24 November 2020
- journal article
- letter
- Published by American Medical Association (AMA) in JAMA
- Vol. 324 (20), 2105
- https://doi.org/10.1001/jama.2020.19410
Abstract
In Reply Dr van den Akker and colleagues propose a possible explanation linking potential deficits in proresolving lipid mediator synthesis to why DHA failed to improve bronchopulmonary dysplasia in both the N3RO1 and MOBYDIck trials.2 As they mentioned, proresolving lipid mediators D and E resolvin series derived from DHA and eicosapentaenoic acid, respectively, have potent roles in the active regulation of inflammatory processes. Arachidonic acid–derived lipoxins appear particularly important for initiating the resolution of the inflammatory cascade.This publication has 4 references indexed in Scilit:
- Effect of Maternal Docosahexaenoic Acid Supplementation on Bronchopulmonary Dysplasia–Free Survival in Breastfed Preterm InfantsJAMA, 2020
- Docosahexaenoic Acid and Arachidonic Acid Levels Are Associated with Early Systemic Inflammation in Extremely Preterm InfantsNutrients, 2020
- A Time-Based Analysis of Inflammation in Infants at Risk of Bronchopulmonary DysplasiaThe Journal of Pediatrics, 2018
- Docosahexaenoic Acid and Bronchopulmonary Dysplasia in Preterm InfantsThe New England Journal of Medicine, 2017