Response to Letter to the Editor from Roy et al: “Impaired Suppression of Glucagon in Obese Subjects Parallels Decline in Insulin Sensitivity and Beta-Cell Function”

Abstract

Roy et al ( 1) analyzed plasma glucagon levels in relation to insulin sensitivity in Asian Indians with normal glucose tolerance (NGT), impaired fasting glucose (IFG), and impaired glucose tolerance (IGT) and found that their observations are mostly consistent with the results seen in Mexican Americans, particularly in the fasting state ( 2). Since underlying metabolic abnormalities in pathogenesis of type 2 diabetes mellitus (T2DM) in different populations should be similar, one should not expect to see major differences in results across different ethnicities.