Recent Advances in the Delivery Carriers and Chemical Conjugation Strategies for Nucleic Acid Drugs
Open Access
- 1 August 2021
- Vol. 13 (15), 3881
- https://doi.org/10.3390/cancers13153881
Abstract
With the development of new anticancer medicines, novel modalities are being explored for cancer treatment. For many years, conventional modalities, such as small chemical drugs and antibody drugs, have worked by “inhibiting the function” of target proteins. In recent years, however, nucleic acid drugs, such as ASOs and siRNAs, have attracted attention as a new modality for cancer treatment because nucleic acid drugs can directly promote the “loss of function” of target genes. Recently, nucleic acid drugs for use in cancer therapy have been extensively developed and some of them have currently been under investigation in clinical trials. To develop novel nucleic acid drugs for cancer treatment, it is imperative that cancer researchers, including ourselves, cover and understand those latest findings. In this review, we introduce and provide an overview of various DDSs and ligand modification technologies that are being employed to improve the success and development of nucleic acid drugs, then we also discuss the future of nucleic acid drug developments for cancer therapy. It is our belief this review will increase the awareness of nucleic acid drugs worldwide and build momentum for the future development of new cancer-targeted versions of these drugs.Funding Information
- Japan Society for the Promotion of Science (20H05871, 20H05874)
- Japan Science and Technology Agency (JPMJPR178A)
- Network Joint Research Center for Materials and Devices (20214025)
This publication has 134 references indexed in Scilit:
- Defined Folate-PEG-siRNA Conjugates for Receptor-specific Gene SilencingMolecular Therapy Nucleic Acids, 2012
- The Tetraspanin CD63 Regulates ESCRT-Independent and -Dependent Endosomal Sorting during MelanogenesisDevelopmental Cell, 2011
- Cellular Uptake and Intracellular Trafficking of Antisense and siRNA OligonucleotidesBioconjugate Chemistry, 2011
- MVB vesicle formation: ESCRT-dependent, ESCRT-independent and everything in betweenCurrent Opinion in Cell Biology, 2011
- Secreted Monocytic miR-150 Enhances Targeted Endothelial Cell MigrationMolecular Cell, 2010
- Molecular mechanism of multivesicular body biogenesis by ESCRT complexesNature, 2010
- Circulating microRNAs as stable blood-based markers for cancer detectionProceedings of the National Academy of Sciences of the United States of America, 2008
- Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesisThe EMBO Journal, 2007
- Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cellsNature, 2007
- A microRNA polycistron as a potential human oncogeneNature, 2005