Hormesis in Health and Disease: Molecular Mechanisms
Open Access
- 2 December 2020
- journal article
- review article
- Published by Secretariat of The Indonesian Biomedical Journal in The Indonesian Biomedical Journal
- Vol. 12 (4), 288-303
- https://doi.org/10.18585/inabj.v12i4.1315
Abstract
BACKGROUND: Hormesis was initially defined as a phenomenon where a small dose of harmful agent exposure to living organisms gives beneficial effects. The dose and time of this ‘tress’ exposure has become the object of investigation across the broad range of biomedical studies. CONTENT: Hormesis characterized by the biphasic dose-effect or time-effect relationship for any substance. Some hormetic mechanisms performed biological plasticity, involve oxidative damage which instead induce antioxidant enzyme production in various cells. Early-life stress can increase resilience in later life and lack of stress can lead to vulnerability. Many stressors like dietary factors and natural environmental toxins can be occupied for healthy growth or homeostasis, which exemplifies how illness is the doorway to health. SUMMARY: Hormesis reconcile many paradoxical phenomena exert opposite effects of the same substance, either a xenobiotic or an endogenous substance, a hormone or a metabolite, a genetic manipulation or an epigenetic alteration, an experimental intervention or a natural event. Human bodies are highly adaptive. A resilient body would be resulted after the ‘training’. In this review, we will elucidate the hormesis’ definition, mechanisms and pathways, and also how hormesis impacts in human health and lifespan. KEYWORDS: biphasic, cell signaling, dose response, hormesis, preconditioningKeywords
This publication has 111 references indexed in Scilit:
- Hormesis provides a generalized quantitative estimate of biological plasticityJournal of Cell Communication and Signaling, 2011
- Inhibition of Respiration Extends C. elegans Life Span via Reactive Oxygen Species that Increase HIF-1 ActivityCurrent Biology, 2010
- The effect of different ubiquinones on lifespan in Caenorhabditis elegansMechanisms of Ageing and Development, 2009
- Caloric restriction alone and with exercise improves CVD risk in healthy non-obese individualsAtherosclerosis, 2009
- The mitochondrial impairment, oxidative stress and neurodegeneration connection: reality or just an attractive hypothesis?Trends in Neurosciences, 2008
- Hormesis definedAgeing Research Reviews, 2008
- Dietary factors, hormesis and healthAgeing Research Reviews, 2008
- Alternate day calorie restriction improves clinical findings and reduces markers of oxidative stress and inflammation in overweight adults with moderate asthmaFree Radical Biology & Medicine, 2007
- Caloric restriction and intermittent fasting: Two potential diets for successful brain agingAgeing Research Reviews, 2006
- Endothelial dysfunction and cardiovascular risk profile in nonalcoholic fatty liver diseaseJournal of Hepatology, 2005