Cellular Trafficking and Subcellular Interactions of Cationic Gene Delivery Nanomaterials
Open Access
- 9 February 2022
- journal article
- Published by Set Publishers in Journal of Pharmacy and Nutrition Sciences
- Vol. 1 (1), 68-81
- https://doi.org/10.6000/1927-5951.2011.01.01.12
Abstract
Various cationic nanobiomaterials have been widely used as gene delivery nanosystems (GDNSs) in vitro and in vivo. Various cellular machineries are involved in trafficking of GDNSs, whose surface functional moieties and architectural properties confer great potential to interact with cell membranes and subcellular biomolecules. It appears such intrinsic inadvertent biological functionalities may impact the outcome of the biomedical applications of these nanobiomaterials. Various advanced materials used as GDNSs may display selective phenotypic effects in target cells/tissues as a result of initiation of various signaling pathways perhaps due to its cellular interactions with plasma cell membranes and/or intracellular compartments including genetic materials. Thus, better understanding about cellular/molecular impacts of GDNSs may maximize their clinical outcomes and accordingly minimize their inevitable undesired consequences. The main focus of this review is based on the cellular trafficking and interactions of cationic gene delivery nanobiomaterials with target cells or subcellular compartments.Keywords
This publication has 75 references indexed in Scilit:
- The application of exosomes as a nanoscale cancer vaccineInternational Journal of Nanomedicine, 2010
- A new feature of the stress response: increase in endocytosis mediated by Hsp70Cell Stress and Chaperones, 2010
- Endocytosis of glycosylphosphatidylinositol-anchored proteinsJournal of Biomedical Science, 2009
- Clathrin-mediated endocytosis and Alzheimer's disease: An updateAgeing Research Reviews, 2009
- Interactions of Poly(amidoamine) Dendrimers with Survanta Lung Surfactant: The Importance of Lipid DomainsLangmuir, 2008
- Cellular binding, motion, and internalization of synthetic gene delivery polymersBiochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2007
- Nanoparticle Interaction with Biological Membranes: Does Nanotechnology Present a Janus Face?Accounts of Chemical Research, 2007
- Polymer genomics: An insight into pharmacology and toxicology of nanomedicinesAdvanced Drug Delivery Reviews, 2006
- Dynamin, endocytosis and intracellular signalling (Review)Molecular Membrane Biology, 1996
- A polycation causes migration of negatively charged phospholipids from the inner to outer leaflet of the liposomal membraneFEBS Letters, 1994