Refractory Pancytopenia and Megaloblastic Anemia due to Falciparum Malaria
- 1 October 2010
- journal article
- case report
- Published by Oxford University Press (OUP) in Journal of Tropical Pediatrics
- Vol. 57 (4), 283-285
- https://doi.org/10.1093/tropej/fmq090
Abstract
Anemia is a common complication in malarial infection. Direct destruction and ineffective erythropoesis does not adequately explain the cause of anemia in malaria. We present a case with refractory megaloblastic anemia with asymptomatic falciparum malaria. We hypothesize that promoter variants in the inducible nitric oxide synthase gene might be the cause of severe refractory megaloblastic anemia and pancytopenia in our patient. Malaria should always be kept in mind as a cause of anemia especially in endemic areas even if the child is asymptomatic or there is no demonstrable parasite on routine smear examination.Keywords
This publication has 10 references indexed in Scilit:
- Factors contributing to anemia after uncomplicated falciparum malaria.The American Journal of Tropical Medicine and Hygiene, 2001
- The intolerable burden of malaria: a new look at the numbersThe American Journal of Tropical Medicine and Hygiene, 2001
- Anaemia of acute malaria infections in non-immune patients primarily results from destruction of uninfected erythrocytesParasitology, 1999
- Evidence for erythrocyte lipid peroxidation in acute falciparum malariaTransactions of the Royal Society of Tropical Medicine and Hygiene, 1999
- Low plasma concentrations of interleukin 10 in severe malarial anaemia compared with cerebral and uncomplicated malariaThe Lancet, 1998
- Reversible suppression of bone marrow response to erythropoietin in Plasmodium falciparum malariaBritish Journal of Haematology, 1997
- The Role of Nitric Oxide in the Regulation of Cellular Iron MetabolismBiochemical and Molecular Medicine, 1997
- Nitric oxide suppression of human hematopoiesis in vitro. Contribution to inhibitory action of interferon-gamma and tumor necrosis factor-alpha.JCI Insight, 1995
- Tumor Necrosis Factor and Disease Severity in Children with Falciparum MalariaThe New England Journal of Medicine, 1989
- Tumour necrosis factor may contribute to the anaemia of malaria by causing dyserythropoiesis and erythrophagocytosisBritish Journal of Haematology, 1988