Prediction of Treatment Response in Mania
- 1 July 1981
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of General Psychiatry
- Vol. 38 (7), 800-3
- https://doi.org/10.1001/archpsyc.1981.01780320080009
Abstract
We evaluated the relation of responsivity of somatic treatment and heterogeneity in a sample of III manics (diagnosed by Feighner criteria) by assessing demographic, clinical, and family illness variables-historical variables potentially related to abnormal brain function and cortical function as measured by neuropsychological and EEG techniques. Except for a positive, perhaps unimportant, relationship between an abnormal EEG and improvement, we could find little evidence for biological differences between responders and nonresponders to treatment. However, 30% of the nonresponders and only 4% of the responders prematurely terminated treatment, suggesting a strong nonbiological mechanism underlying treatment failure. We conclude that there are as yet no adequate predictors of short-term treatment response in mania and that evidence for heterogeneity in mania must be sought elsewhere.Keywords
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