The objective of this review is to bring general awareness amongst the population regarding the general healthy practices of social distancing, maintaining hygiene by use of various hand sanitizers, and ensuring prevention of the spread of COVID-19 infection. The general population may be concerned about the effectiveness and safety aspects of alcohol-based hand sanitizers. The harmful effects that might be associated with the excessive use of alcohol-based hand sanitizers. The current article tries to focus on the various ways by which sanitization may be achieved. It also describes the various types of alcohol-based hand sanitizers and extensively talks about their manufacturing methods of them. The queries regarding the hazardous effects of alcohol-based hand sanitizers are also addressed.