Study of significance of Serum Cystatin-C and Vascular Endothelial Growth Factor as an early marker of diabetic nephropathy in type 2 diabetes patients

Abstract

Aim: To determine the usefulness of serum cystatin-C along with vascular endothelial growth factor (VEGF) as an early marker of diabetic nephropathy. Method: The study includes diabetic patients visiting the Medicine OPD and was divided into groups according to duration of diabetes. Group 1 with diabetes between 5-10 years, group 2 with diabetes between 10-15 years, group 3 with diabetes more than 15 years and control group. Results: Serum cystatin-C and VEGF level raised significantly in group 2 patients (10-15 years duration) and increases further with the progression of disease. Conclusion: Both cystatin-C and vascular endothelial growth factor can be useful marker of early diabetic nephropathy in patients with type 2 diabetes.