Epigenetic priming targets tumor heterogeneity to shift transcriptomic phenotype of pancreatic ductal adenocarcinoma towards a Vitamin D susceptible state
Preprint
- 23 May 2023
- preprint
- Published by Research Square Platform LLC
Abstract
As a highly heterogeneous tumor, pancreatic ductal adenocarcinoma (PDAC) exhibits non-uniform responses to therapies across subtypes. Overcoming therapeutic resistance due to tumor heterogeneity in PDAC remains a challenge. Here, we report that Vitamin D-resistant PDAC cells hijacked Vitamin D...Keywords
Other Versions
- Published version: Version Cell Death & Disease, 15, preprints
This publication has 46 references indexed in Scilit:
- 5-Azacytidine/5-AzacitidineRecent Results in Cancer Research, 2014
- SOX15 is a candidate tumor suppressor in pancreatic cancer with a potential role in Wnt/β-catenin signalingOncogene, 2013
- Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapyNature Medicine, 2011
- Hedgehog signaling and therapeutics in pancreatic cancerCarcinogenesis: Integrative Cancer Research, 2010
- edgeR: a Bioconductor package for differential expression analysis of digital gene expression dataBioinformatics, 2009
- Sonic hedgehog paracrine signaling regulates metastasis and lymphangiogenesis in pancreatic cancerOncogene, 2009
- Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profilesProceedings of the National Academy of Sciences of the United States of America, 2005
- Progress toward Acetate Supplementation Therapy for Canavan Disease: Glyceryl Triacetate Administration Increases Acetate, but NotN-Acetylaspartate, Levels in BrainThe Journal of pharmacology and experimental therapeutics, 2005
- Histone deacetylases and cancer: causes and therapiesNature Reviews Cancer, 2001
- Inhibitory effect of 220-oxa-1,25-dihydroxyvitamin D3 on the proliferation of pancreatic cancer cell linesGastroenterology, 1996