Efficacy, tolerability and safety study of zinc hyaluronan for dogs with osteoarthritis

Abstract

Relevance. In recent years, the problems of arthrology have become more relevant among domestic and farm animals. The significance of the article is due to the fact that in the Russian market of veterinary drugs, there is obviously a small number of drugs for the treatment of various pathologies of the joints, created on the basis of hyaluronic acid.Methods. 32 dogs of different sexes and breeds aged from 8 to 13 years with destructive-degenerative pathologies of the joints were selected for the study. Animals were treated with hyaluronic acid with zinc. Research methods: hematological analysis, general clinical examination.Results. In the process of drug therapy, in 81.25% of dogs was noted an increase in motor activity. Also, 7 days after the 5th injection of the drug, there was a significant decrease in the manifestations of starting pains up to their complete absence. The main positive changes in the course of arthrosis in dogs, according to all evaluation criteria, reached their maximum manifestation after 3–4th injections and remained practically unchanged by the 5th injection. The results of a biochemical study of blood serum indicate that against the background of the use of the drug in dogs with osteoarthritis, no significant changes were found that characterize the main types of metabolism. According to the results of hematological studies, it can be noted that in dogs receiving therapy with hyaluronic acid with zinc, there is a steady positive trend in a number of hematological parameters. So, a week after the 5th injection of the “Drug” there was a decrease in the total number of platelets. The percentage of eosinophils in the leukocyte formula stabilized to the upper values of the reference range. It is appropriate to emphasize that the “Drug” does not exhibit the properties of an antigen, and has a pronounced anti-inflammatory effect.