The scope, limitations and interpretation of copy number detection in the early embryo using the array CGH technique

Abstract

In the current issue Mertzanidou et al. (2012) report a detailed chromosome study of cleavage-stage embryos using a version of the array comparative genomic hybridization (aCGH) technique. The aCGH technique is widely used in the genetics field and this study provides an opportunity to offer some guidance to the journal reader on its scope and limitations when applied to early human embryos, and the interpretation of the complex results sometimes obtained.