Comment notice of: Microarray analysis reveals abnormal chromosomal complements in over 70% of 14 normally developing human embryos
The scope, limitations and interpretation of copy number detection in the early embryo using the array CGH technique
Human Reproduction
,
Volume 28,
pp 2-5; https://doi.org/10.1093/humrep/des366
Abstract: In the current issue Mertzanidou et al. (2012) report a detailed chromosome study of cleavage-stage embryos using a version of the array comparative genomic hybridization (aCGH) technique. The aCGH technique is widely used in the genetics field and this study provides an opportunity to offer some guidance to the journal reader on its scope and limitations when applied to early human embryos, and the interpretation of the complex results sometimes obtained.
Keywords: copy number / Embryos / chromosome / Journal / scope / cleavage / Reader / Acgh
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