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Relapse of minimal change disease following the AstraZeneca COVID-19 vaccine

, Sally El-Kateb, Praveen Jeevaratnam, Barbara Thompson
Published: 9 June 2021

Abstract: Anecdotal reports linking minimal change disease (MCD) to vaccinations possibly due to immune dysregulation,1Clajus C. Spiegel J. Brocker V. et al.Minimal change nephrotic syndrome in an 82 year old patient following a tetanus-diphtheria-poliomyelitis-vaccination.BMC Nephrol. 2009; 10: 21Crossref PubMed Scopus (6) Google Scholar including influenza vaccine,2Kielstein J.T. Termuhlen L. Sohn J. Minimal change nephrotic syndrome in a 65-year-old patient following influenza vaccination.Clin Nephrol. 2000; 54: 246-248PubMed Google Scholar pneumococcal,3Kikuchi Y. Imakiire T. Hyodo T. et al.Minimal change nephrotic syndrome, lymphadenopathy and hyperimmunoglobulinemia after immunization with a pneumococcal vaccine.Clin Nephrol. 2002; 58: 68-72Crossref PubMed Google Scholar meningococcal C vaccines,4Abeyagunawardena A. Goldblatt D. Andrews N. Trompeter R. Risk of relapse after meningococcal C conjugate vaccine in nephrotic syndrome.Lancet. 2003; 362: 449-450Abstract Full Text Full Text PDF PubMed Scopus (38) Google Scholar and BNT162b2 coronavirus disease 2019 (COVID-19) vaccine (Pfizer-BioNTech)5Lebedev L, Sapojnikov M, Wechsler A, et al. Minimal change disease following the Pfizer-BioNTech COVID-19 vaccine [e-pub ahead of print]. Am J Kidney Dis. Accessed June 20, 2021.Google Scholar,6D’Agati VD, Kudose S, Bomback AS, et al. Minimal change disease and acute kidney injury following the Pfizer-BioNTech COVID-19 vaccine [e-pub ahead of print]. Kidney Int. Scholar have been published. We report 2 cases of biopsy-proven MCD relapsing within 2 days of receiving an AstraZeneca COVID-19 vaccine.
Keywords: vaccine / COVID / Minimal change disease / Nephrol / BioNTech / Pfizer / relapsing

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