Formula Optimization of Annona muricata Folium Ethanolic Extract of Anti Acne Gel Formulation using Factorial Design Method
Open Access
- 14 November 2019
- journal article
- Published by Universitas Muhammadiyah Palangkaraya in Borneo Journal of Pharmacy
- Vol. 2 (2), 63-70
- https://doi.org/10.33084/bjop.v2i2.981
Abstract
Acne is a pile of oil glands in the skin that are actively being clogged by dirt and infection because of Propionibacterium acnes, Staphylococcus aureus, and Staphylococcus epidermidis. The treatment for acne can use herbal ingredients, one of which is Soursop (Annona muricata L.) leaves ethanolic extract. Annona muricata folium ethanolic extract is known to have alkaloid, flavonoid and polyphenol compounds which can inhibit the growth of P. acnes, S. epidermidis, and S. aureus. Suitable dosage forms for anti-acne preparations are gels because the gel contains much water so that it provides a cooling effect on the skin due to inflammation. The purpose of this study was to determine the impact of carbopol 940 and Propylene glycol on the physical characteristics of the gel preparation and determine the optimum formula of the gel preparation using factorial design software 22 so that the gel preparation was made in four formulas. The data obtained were then analyzed using Design-Expert� and ANOVA software with a confidence level of 95%, and the determination of the optimum formula based on the optimum superimposed contour plot area. The results of the study using a factorial design approach are known that Propylene glycol has an effect on increasing the spreadability and pH while carbopol 940 has a more significant impact on the increase in adhesion and viscosity, and the optimum area of ??the composition of carbopol 940 1.536% and propylene glycol 5% was obtained.Keywords
This publication has 20 references indexed in Scilit:
- Phytochemical analysis, antioxidant, antibacterial and cytotoxicity properties of keys and cores part of Pandanus tectorius fruitsArabian Journal of Chemistry, 2019
- Review of Alternative Solvents for Green Extraction of Food and Natural Products: Panorama, Principles, Applications and ProspectsMolecules, 2019
- Aktivitas Antibakteri Minyak Sirih Merah (Piper Crocatum Ruiz & Pav.) Dalam Bentuk Sediaan Emulsi dan MikroemulsiMajalah Farmaseutik, 2019
- Formulation of Snail Slime (Achatina Fulica) Anti-Acne Emulgel using Tween 80-Span 80 as Emulsifying and HPMC as Gelling AgentBorneo Journal of Pharmacy, 2018
- PENGARUH VARIASI JENIS DAN KONSENTRASI GELLING AGENT TERHADAP SIFAT FISIK GEL HIDROKORTISONJurnal Farmasi Sains dan Praktis, 2018
- Optimasi Pembentuk Film Polivinil Alkohol dan Humektan Propilen Glikol pada Formula Masker Gel Peel off Sari Buah Labu Kuning (Cucurbita moschata Duchesne) sebagai AntioksidanJurnal Farmasi Galenika (Galenika Journal of Pharmacy), 2017
- Ekstraksi Tanin pada Daun Ketapang (Terminalia Catappa L) dengan Variasi Pelarut, Konsentrasi Pelarut dan Lama Waktu EkstraksiJURNAL AGROINDUSTRI HALAL, 2017
- Development and Evaluation of Stability of a Gel Formulation Containing the Monoterpene BorneolThe Scientific World Journal, 2016
- Propionibacterium acnes: from Commensal to Opportunistic Biofilm-Associated Implant PathogenClinical Microbiology Reviews, 2014
- Generic Development of Topical Dermatologic Products: Formulation Development, Process Development, and Testing of Topical Dermatologic ProductsThe AAPS Journal, 2012