Abnormal sperm morphology is associated with sensitization to inhaled allergens
Open Access
- 5 January 2022
- journal article
- research article
- Published by SAGE Publications in International Journal of Immunopathology and Pharmacology
Abstract
Background: Allergy is associated with the loss of tolerance of environmental antigens, combined with a pathological immune response. There were no studies up to date that would show whether the quality of semen decreases in people with allergic diseases. Material and methods: The research included men who reported to the Gynecological Outpatient Clinic due to reproductive difficulties, defined as the lack of pregnancy after one year of regular intercourse. Semen quality was assessed according to the World Health Organization (WHO) standard. All patients underwent skin prick tests with the most important inhalation allergens (such as hazel, silver birch, mugwort, rye, dog, cat, Dermatophagoides farinae, Dermatophagoides pteronyssinus, alder, Alternaria alternata, Cladosporium herbarum, and grass mix). The data was statistically analyzed. Results: Results of 52 patients aged 25–52 years (34.62 ± 4.96) were analyzed. The mean BMI (Body mass index) was 28.25 (+ −3.77). It was found that 38 men (73%) had increased body weight, and 14 men (26.9%) were obese (BMI > = 30). 13 patients were smokers (25%), and 24 patients (46%) had skin tests positive for at least one inhaled allergen. Sperm tail defects were statistically more significant in patients allergic to birch, rye, cat, alder, and grass. In patients allergic to Alternaria alternata, head defects were statistically more significant (p < .05). No association was found between allergy to house dust mites, mugwort, hazel, and dogs and the deterioration of semen. Conclusion: Allergy due to inhalation allergens had an influence on the quality of male semen. Further research is necessary to establish the immunological bases of this phenomenon.Keywords
This publication has 40 references indexed in Scilit:
- The skin prick test – European standardsClinical and Translational Allergy, 2013
- An exploration of the association between male body mass index and semen qualityReproductive BioMedicine Online, 2011
- Characterization of patients with suspected seminal plasma hypersensitivityAllergy and Asthma Proceedings, 2011
- The impact of body mass index on semen parameters and reproductive hormones in human males: a systematic review with meta-analysisHuman Reproduction Update, 2009
- Epidemiology and management of infertility: a population-based study in UK primary careFamily Practice, 2009
- Mast cells in the seminal plasma of infertile men as detected by flow cytometryAndrologia, 2009
- Sensitization to wasp venom does not induce autoantibodies leading to infertilityMolecular Immunology, 2008
- Pathophysiology of sperm motilityFrontiers in Bioscience-Landmark, 2006
- Human seminal plasma anaphylaxis (HSPA): case report and literature reviewAllergy, 1995
- Anaphylactic sensitivity to human seminal fluidClinical & Experimental Allergy, 1974