Premenopausal syndrome is experienced by women almost all over the world, such as 70-80% of women in Europe, 60% of women in America, 57% of women in Malaysia, 18% of women in China, and 10% of women in Japan and Indonesia. Indonesia's population is estimated at 240-250 million, there are about 30-40 million elderly women, where every year the anxiety rate is increasing, the prevalence of anxiety (anxiety) in Indonesia ranges from 2-5% of the general population or 7-16% of the population. all people with mental disorders. The purpose of this study was to determine the relationship between characteristics and level of knowledge on anxiety in pre-menopausal women in Selomanik Village, Kaliwiro District. This research was conducted in Selomanik Village, Kaliwiro District, using correlation analytic with cross sectional time approach. Sampling technique with stratified random sampling. Data were analyzed by univariate and bivariate using chi-square statistical test. The results of the bivariate test showed that there was a relationship between characteristics and knowledge with pre-menopausal women's anxiety as evidenced by the p value < 0.05. The results of this study are expected that women who will experience menopause are calmer/ less anxious if they experience menopause symptoms and are more prepared to face menopause. ABSTRAK Sindrom pre menopause banyak dialami oleh wanita hampir diseluruh dunia, seperti 70-80% wanita di Eropa, 60% wanita di Amerika, 57% wanita di Malaysia, 18% wanita di Cina, dan 10% wanita di Jepang dan Indonesia, dari seluruh jumlah penduduk Indonesia yang diperkirakan sebesar 240-250 juta, terdapat sekitar 30-40 juta wanita lansia, dimana setiap tahunnya angka kecemasan semakin meningkat, prevalensi keadaan kecemasan (anxietas) di Indonesia berkisar antara 2-5% dari populasi umum atau 7-16% dari semua penderita gangguan jiwa. Tujuan dalam penelitian ini dilakukan untuk mengetahui hubungan karakteristik dan tingkat pengetahuan terhadap kecemasan pada wanita pre menopause di Desa Selomanik, Kecamatan Kaliwiro. Jenis penelitian ini adalah analitik korelasi dengan pendekatan waktu cross sectional. Tehnik pengambilan sampel dengan stratifed random sampling.Data dianalisis secara univariat dan bivariat menggunakan uji statistic chi-square. Hasil uji bivariat menunjukkan ada hubungan antara karakteristik dan pengetahuan dengan kecemasan wanita pre menopause dibuktikan dengan hasil p value < 0.05. Hasil penelitian ini diharapkan bahwa wanita yang akan mengalami menopause lebih tenang/ tidak cemas jika mengalami gejala menopause dan lebih siap menghadapi menopause.