Characteristics of Helicobacter pylori-seropositive subjects according to the stool antigen test findings: a prospective study
Open Access
- 1 September 2018
- journal article
- research article
- Published by Korean Association of Internal Medicine in The Korean Journal of Internal Medicine
- Vol. 33 (5), 893-901
- https://doi.org/10.3904/kjim.2016.353
Abstract
Background/Aims: In countries with a higher risk of gastric atrophic gastritis, noninvasive tests are helpful for a more reliable diagnosis of Helicobacter pylori infection. The aim of this study was to evaluate the characteristics of seropositive subjects according to their stool H. pylori antigen test, serum pepsinogen (PG) assay, and endoscopic findings. Methods: Consecutive subjects who visited Konkuk University Medical Center for upper gastrointestinal endoscopy for a regular check-up were included in a prospective setting if the serum anti-H. pylori immunoglobulin G assay was positive. A H. pylori antigen stool test was measured using a stool H. pylori antigen enzyme-linked immunosorbent assay kit on the same day as a serum PG assay and endoscopy. Results: Of 318 seropositive subjects, 256 (80.5%) showed positive stool test findings. Subjects with a negative stool test result showed lower serum PG I (p < 0.001) and PG II (p < 0.001) levels and higher PG I/II ratio (p < 0.001) than those with a positive stool test. Chronic atrophic gastritis was more common in the positive stool test group than the negative stool test group on endoscopic finding (p = 0.009). A higher serum PG I level (p = 0.001) and a lower serum PG I/II ratio (p = 0.001) were independent risk factors for the presence of H. pylori antigen in stool. Conclusions: A high serum PG level denotes an ongoing current H. pylori infection with positive stool a pylori antigen test findings. Seropositive subjects with increased gastric secreting ability tend to have H. pylori in their fecal material as reflected by a positive stool H. pylori antigen test finding.Keywords
Funding Information
- National Research Foundation of Korea (2016R1D1A1B02008937)
This publication has 26 references indexed in Scilit:
- Comparison of the Diagnostic Accuracy of Five Different Stool Antigen Tests for the Diagnosis of Helicobacter pylori InfectionHelicobacter, 2013
- Prospective evaluation of a new stool antigen test for the detection of Helicobacter pylori, in comparison with histology, rapid urease test, 13C‐urea breath test, and serologyJournal of Gastroenterology and Hepatology, 2011
- Interobserver variations in histopathological assessment of gastric pathologyPathology, 2009
- LONG‐TERM RESULTS OF GASTRIC CANCER SCREENING USING THE SERUM PEPSINOGEN TEST METHOD AMONG AN ASYMPTOMATIC MIDDLE‐AGED JAPANESE POPULATIONDigestive Endoscopy, 2009
- Comparison of a Stool Antigen Test and Serology for the Diagnosis of Helicobacter pylori Infection in Mass SurveyHelicobacter, 2009
- Comparison of a monoclonal with a polyclonal antibody-based enzyme immunoassay stool test in diagnosing Helicobacter pylori infection before and after eradication therapyAlimentary Pharmacology & Therapeutics, 2006
- Helicobacter pylori stool antigen test in patients with bleeding peptic ulcersHelicobacter, 2004
- Utility and limitations of a method for detecting Helicobacter pylori -specific antigens in the stoolThe Esophagus, 2003
- Accuracy of the stool antigen test in the diagnosis of Helicobacter pylori infection before treatment and in patients on omeprazole therapyAlimentary Pharmacology & Therapeutics, 2001
- Diagnosis of Helicobacter pylori Infection in Patients with Atrophic Gastritis: Comparison of Histology, 13C-Urea Breath Test, and SerologyScandinavian Journal of Gastroenterology, 2000