A strategy to impute age at onset of a particular condition from external sources
- 26 May 2021
- journal article
- research article
- Published by SAGE Publications in Statistical Methods in Medical Research
- Vol. 30 (8), 1771-1781
- https://doi.org/10.1177/09622802211013830
Abstract
A key hypothesis in epidemiological studies is that time to disease exposure provides relevant information to be considered in statistical models. However, the initiation time of a particular condition is usually unknown. Therefore, we developed a multiple imputation methodology for the age at onset of a particular condition, which is supported by incidence data from different sources of information. We introduced and illustrated such a methodology using simulated data in order to examine the performance of our proposal. Then, we analyzed the association of gallstones and fatty liver disease in the Maule Cohort, a Chilean study of chronic diseases, using participants’ risk factors and six sources of information for the imputation of the age-occurrence of gallstones. Simulated studies showed that an increase in the proportion of imputed data does not affect the quality of the estimated coefficients associated with fully observed variables, while the imputed variable slowly reduces its effect. For the Chilean study, the categorized exposure time to gallstones is a significant variable, in which participants who had short and long exposure have, respectively, 26.2% and 29.1% higher chance of getting a fatty liver disease than non-exposed ones. In conclusion, our multiple imputation approach proved to be quite robust both in the linear/logistic regression simulation studies and in the real application, showing the great potential of this methodology.Funding Information
- Fondo de Financiamiento de Centros de Investigación en Áreas Prioritarias (15130011)
- Fondo Nacional de Desarrollo Científico y Tecnológico (1170395)
This publication has 18 references indexed in Scilit:
- Association Between Cholecystectomy and Nonalcoholic Fatty Liver Disease: A Meta‐analysisWorld Journal of Surgery, 2016
- Study protocol for the Maule Cohort (MAUCO) of chronic diseases, Chile 2014–2024BMC Public Health, 2015
- Editorial : Cholecystectomy and NAFLD: Does Gallbladder Removal Have Metabolic Consequences?The American Journal of Gastroenterology, 2013
- How many are affected? A real limit of epidemiologyEpidemiologic Perspectives & Innovations, 2010
- A method to predict breast cancer stage using Medicare claimsEpidemiologic Perspectives & Innovations, 2010
- Risk factor studies of age-at-onset in a sample ascertained for Parkinson disease affected sibling pairs: a cautionary taleEmerging Themes in Epidemiology, 2007
- An introduction to finite mixture distributionsStatistical Methods in Medical Research, 1996
- Frequency of gallbladder cancer in chile, A high‐risk areaInternational Journal of Cancer, 1988
- Epidemiology of Gallstones in a German Industrial Town (Essen) from 1940–1975Digestion, 1986
- A new look at the statistical model identificationIEEE Transactions on Automatic Control, 1974