Excellent Repigmentation of Generalized Vitiligo with Oral Baricitinib Combined with NB-UVB Phototherapy
Open Access
- 1 March 2023
- journal article
- research article
- Published by Taylor & Francis Ltd in Clinical, Cosmetic and Investigational Dermatology
- Vol. ume 16, 635-638
- https://doi.org/10.2147/ccid.s396430
Abstract
Vitiligo is an acquired autoimmune skin disorder, clinically characterized by distinct white macules and patches resulting from progressive melanocyte destruction. JAK-STAT pathway plays an important role in the loss of epidermal melanocytes. Baricitinib can block the JAK-STAT pathway and the downstream chemokines as a new JAK1/2 inhibitor. In this report, we describe the successful treatment of 2 patients with oral baricitinib combined with NB-UVB phototherapy, which provides a good alternative and supplementary to treat refractory vitiligo.Keywords
This publication has 10 references indexed in Scilit:
- Baricitinib is Effective in Treating Progressing Vitiligo in vivo and in vitroDose-Response, 2022
- How suitable are JAK inhibitors in treating the inflammatory component in patients with alopecia areata and vitiligo?Expert Review of Clinical Immunology, 2022
- Photodynamic therapy of vitiligo: A pilot studyPhotodiagnosis and Photodynamic Therapy, 2021
- Repigmentation of vitiligo with oral baricitinibAustralasian Journal of Dermatology, 2020
- Vitiligo: Mechanisms of Pathogenesis and TreatmentAnnual Review of Immunology, 2020
- The Use of Janus Kinase Inhibitors in Vitiligo: A Review of the LiteratureJournal of Cutaneous Medicine and Surgery, 2019
- Expression of Janus Kinase 1 in vitiligo & psoriasis before and after narrow band UVB: a case–control studyArchiv für dermatologische Forschung, 2017
- Jak-inhibitors and UV-B: Potential combined therapy for vitiligoDermatologic Therapy, 2017
- Repigmentation in vitiligo using the Janus kinase inhibitor tofacitinib may require concomitant light exposureJournal of the American Academy of Dermatology, 2017
- Narrowband ultraviolet B phototherapy in combination with other therapies for vitiligo: mechanisms and efficaciesJournal of the European Academy of Dermatology and Venereology, 2014