The ins and outs of SARS-CoV-2 variants of concern (VOCs)
- 28 January 2022
- journal article
- review article
- Published by Springer Science and Business Media LLC in Archiv für die gesamte Virusforschung
- Vol. 167 (2), 327-344
- https://doi.org/10.1007/s00705-022-05365-2
Abstract
SARS-CoV-2, a newly emerging coronavirus that caused the COVID-19 epidemic, has been spreading quickly throughout the world. Despite immunization and some fairly effective therapeutic regimens, SARS-CoV-2 has been ravaging patients, health workers, and the economy. SARS-CoV-2 mutates and evolves to adapt to its host as a result of extreme selection pressure. As a consequence, new SARS-CoV-2 variants have emerged, some of which are classified as variants of concern (VOC) because they exhibit greater transmissibility, cause more-severe disease, are better able to escape immunity, or cause higher mortality than the original Wuhan strain. Here, we introduce these VOCs and review their characteristics, such as transmissibility, immune escape, mortality risk, and diagnostics.This publication has 168 references indexed in Scilit:
- Antibody cocktail to SARS-CoV-2 spike protein prevents rapid mutational escape seen with individual antibodiesScience, 2020
- Black–White Risk Differentials in COVID-19 (SARS-COV2) Transmission, Mortality and Case Fatality in the United States: Translational Epidemiologic Perspective and ChallengesInternational Journal of Environmental Research and Public Health, 2020
- The D614G mutation in the SARS-CoV-2 spike protein reduces S1 shedding and increases infectivityPublished by Cold Spring Harbor Laboratory ,2020
- A Review on SARS-CoV-2 Virology, Pathophysiology, Animal Models, and Anti-Viral InterventionsPathogens, 2020
- Coronavirus protective immunity is short-lastingPublished by Cold Spring Harbor Laboratory ,2020
- Insulin-like growth factor 1-induced enolase 2 deacetylation by HDAC3 promotes metastasis of pancreatic cancerSignal Transduction and Targeted Therapy, 2020
- Seasonality and immunity to laboratory-confirmed seasonal coronaviruses (HCoV-NL63, HCoV-OC43, and HCoV-229E): results from the Flu Watch cohort studyWellcome Open Research, 2020
- Bi-directional differentiation of single bronchioalveolar stem cells during lung repairCell Discovery, 2020
- Structural and molecular basis of mismatch correction and ribavirin excision from coronavirus RNAProceedings of the National Academy of Sciences of the United States of America, 2017
- Expression, purification, and characterization of SARS coronavirus RNA polymeraseVirology, 2005