Time trends of coronary procedures, guideline-based drugs and all-cause mortality following acute coronary syndrome in patients with bipolar disorder
- 29 July 2022
- journal article
- research article
- Published by Taylor & Francis Ltd in Nordic Journal of Psychiatry
- Vol. 77 (3), 1-8
- https://doi.org/10.1080/08039488.2022.2102208
Abstract
This study analyzed time trends in the use of coronary procedures, guideline-based drugs, and 1-year all-cause and presumed cardiovascular mortality (CV) following acute coronary syndrome (ACS) in patients with and without bipolar disorder (BD). Using Danish registries 497 patients with ACS and BD in the period 1996–2016 were matched 1:2 on age, sex and year of ACS to patients without preexisting psychiatric disease. Patients with BD and ACS received fewer coronary angiography (CAG) compared to psychiatric healthy controls (PHC). However, the difference between the populations decreased over time. For percutaneous coronary intervention (PCI) and coronary artery bypass (CABG) no differences in trend over time were found. In general patients with BD redeemed fewer prescriptions of guideline-based tertiary prophylactic drugs compared to PHCs. The difference remains constant over time for all drugs except for acetylsalicylic acid, lipid-lowering drugs and beta blockers, where the difference decreased. The 1-year all-cause mortality gap and the presumed CV mortality gap remained unchanged. Despite improvements in treatment disparities regarding CAG, acetylsalicylic acid, lipid-lowering drugs and beta-blockers, the treatment gap remained unchanged concerning PCI and CABG. Likewise, patients with BD experienced a lower rate of the remaining redeemed prescriptions. The overall crude mortality risk ratio for patients with BD experiencing ACS remained unchanged over the study period compared to PHC.Keywords
Funding Information
- Lundbeck Pharma A/S
- Danish Heart Foundation
- Eva and Henry Fraenkel Memorial Foundation
- Karl G. Andersens Foundation
- Lundbeck
- Otsuka
- Teva
- Eli Lilly
This publication has 33 references indexed in Scilit:
- The Danish Civil Registration System as a tool in epidemiologyEuropean Journal of Epidemiology, 2014
- Multimorbidity in bipolar disorder and undertreatment of cardiovascular disease: a cross sectional studyBMC Medicine, 2013
- Cardiovascular drug use and mortality in patients with schizophrenia or bipolar disorder: a Danish population-based studyPsychological Medicine, 2013
- Cardiovascular mortality in bipolar disorder: a population-based cohort study in SwedenBMJ Open, 2013
- Diagnostic Procedures, Revascularization, and Inpatient Mortality After Acute Myocardial Infarction in Patients With Schizophrenia and Bipolar DisorderPsychosomatic Medicine, 2013
- A Tale of Coronary Artery Disease and Myocardial InfarctionThe New England Journal of Medicine, 2012
- The Danish Psychiatric Central Research RegisterScandinavian Journal of Public Health, 2011
- The Danish Register of Causes of DeathScandinavian Journal of Public Health, 2011
- Validation of risk stratification schemes for predicting stroke and thromboembolism in patients with atrial fibrillation: nationwide cohort studyBMJ, 2011
- Cardiovascular disease and diabetes in people with severe mental illness position statement from the European Psychiatric Association (EPA), supported by the European Association for the Study of Diabetes (EASD) and the European Society of Cardiology (ESC)European Psychiatry, 2009