A Clinicopathologic Study of Seven Cases of Orbital Solitary Fibrous Tumours
Open Access
- 24 May 2020
- journal article
- research article
- Published by Springer Science and Business Media LLC in Cureus
- Vol. 12 (5), e8259
- https://doi.org/10.7759/cureus.8259
Abstract
To describe the patient demographics, clinical findings, investigations, surgical outcomes, and histopathological findings of seven cases of orbital solitary fibrous tumours. This was a retrospective review of seven cases of orbital solitary fibrous tumour, which were followed up in Hospital Serdang, a national oculoplastic centre, from years 2008-2017. This study included seven patients with ages between 21 and 35 years old; two were males and five were females. All seven patients presented with painless chronic unilateral proptosis. Radiological imaging of the orbit showed a localized contrast enhancing intraorbital mass. All patients underwent orbitotomy and excisional biopsy. Intraoperative findings showed a well-encapsulated and vascularized mass. Histological findings of spindle-shaped cells were noted. All cases had positive staining for cluster of differentiation (CD) 34, five were positive for CD 99, four were positive for B-cell lymphoma (BCL-2), and five patients had positive staining for S-100. Three of the patients did not have clear margins during the primary operation and subsequently had a recurrence within two years. A solitary fibrous tumour is a rare mesenchymal tumour with a pleural origin. The orbit is the most common extrapleural site of the tumour and they are usually benign. Immunohistochemistry is important to differentiate it from other, more aggressive forms of orbital tumours. Regular follow-up is important to monitor for recurrence.This publication has 12 references indexed in Scilit:
- Solitary fibrous tumor of the orbitJournal of Cancer Research and Therapeutics, 2019
- Sinonasal Tract Solitary Fibrous Tumor: A Clinicopathologic Study of Six Cases with a Comprehensive Review of the LiteratureHead and Neck Pathology, 2017
- Correlation between Clinical Features, Imaging and Pathologic Findings in Recurrent Solitary Fibrous Tumor of the OrbitOrbit, 2013
- Malignant transformation of orbital solitary fibrous tumorInternational Ophthalmology, 2013
- A Solitary Fibrous Tumor with Giant Cells in the Lacrimal Gland: A Case StudyThe Korean Journal of Pathology, 2013
- Orbital solitary fibrous tumor: A clinicopathologic correlation and review of literatureOman Journal of Ophthalmology, 2011
- Solitary Fibrous Tumor of the Orbit: A Case SeriesOrbit, 2008
- Solitary Fibrous Tumor of the Orbit in a ChildOphthalmic Plastic & Reconstructive Surgery, 2001
- Solitary fibrous tumorCancer, 1997
- Solitary Fibrous Tumor Consistent CD34 Immunoreactivity and Occurrence in the OrbitThe American Journal of Surgical Pathology, 1994