Neuroendocrine Neoplasms of the Pancreas: Diagnostic Challenges and Practical Approach
- 22 September 2022
- journal article
- review article
- Published by Ovid Technologies (Wolters Kluwer Health) in Advances in Anatomic Pathology
- Vol. 30 (1), 58-68
- https://doi.org/10.1097/pap.0000000000000369
Abstract
Most pancreatic neuroendocrine neoplasms are slow-growing, and the patients may survive for many years, even after distant metastasis. The tumors usually display characteristic organoid growth patterns with typical neuroendocrine morphology. A smaller portion of the tumors follows a more precipitous clinical course. The classification has evolved from morphologic patterns to the current World Health Organization classification, with better-defined grading and prognostic criteria. Recent advances in molecular pathology have further improved our understanding of the pathogenesis of these tumors. Various issues and challenges remain, including the correct recognition of a neuroendocrine neoplasm, accurate classification and grading of the tumor, and differentiation from mimickers. This review focuses on the practical aspects during the workup of pancreatic neuroendocrine neoplasms and attempts to provide a general framework to help achieve an accurate diagnosis, classification, and grading.Keywords
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