A method is proposed for calculating the normal compaction curve of rocks for the deep parts of the lithosphere. It is based on the analysis of petrophysical characteristics and interpretation of gravitational anomalies. The main regularities of density changes in the lithosphere of Northern Eurasia are investigated. It has been shown that the density section of the region’s lithosphere is characterized by alternation of paragenetically connected decompacted-compacted (relative to normal compaction) rock complexes at all levels of the lithosphere from the surface layers of bottom sediments to the mantle. These zones of decompacted-compacted rocks complexes have a global distribution.