Recent evaluation about inflammatory mechanisms in nonalcoholic fatty liver disease
Open Access
- 16 March 2023
- journal article
- review article
- Published by Frontiers Media SA in Frontiers in Pharmacology
- Vol. 14, 1081334
- https://doi.org/10.3389/fphar.2023.1081334
Abstract
Non-alcoholic fatty liver disease (NAFLD) is common chronic metabolic liver disorder which is associated with fat accumulation in the liver. It causes a wide range of pathological effects such as insulin resistance, obesity, hypertension, diabetes, nonalcoholic steatohepatitis (NASH) and cirrhosis, cardiovascular diseases. The molecular mechanisms that cause the initiation and progression of NAFLD remain fully unclear. Inflammation is regarded as a significant mechanism which could result in cell death and tissue injury. Accumulation of leukocytes and hepatic inflammation are important contributors in NAFLD. Excessive inflammatory response can deteriorate the tissue injury in NAFLD. Thus, inhibition of inflammation improves NAFLD by reducing intrahepatic fat content, increasing β-oxidation of fatty acids, inducing hepato-protective autophagy, overexpressing peroxisome proliferator-activated receptor- γ (PPAR-γ), as well as attenuating hepatocyte apoptosis and increasing insulin sensitivity. Therefore, understanding the molecules and signaling pathways suggests us valuable information about NAFLD progression.This review aimed to evaluate the inflammation in NAFLD and the molecular mechanism on NAFLD.This publication has 70 references indexed in Scilit:
- Prevention of hepatic fibrosis with liver microsomal triglyceride transfer protein deletion in liver fatty acid binding protein null miceJournal of Hepatology, 2016
- Pathogenesis of Nonalcoholic SteatohepatitisGastroenterology, 2016
- Nonalcoholic Fatty Liver Disease: Pathogenesis and Disease SpectrumAnnual review of pathology, 2016
- Innate Immunity and Inflammation in NAFLD/NASHDigestive Diseases and Sciences, 2016
- Global epidemiology of nonalcoholic fatty liver disease—Meta‐analytic assessment of prevalence, incidence, and outcomesJournal of Hepatology, 2015
- Nonalcoholic Fatty Liver Disease, Cardiovascular Risk, and Carotid InflammationAngiology, 2014
- The role of liver fat and insulin resistance as determinants of plasma aminotransferase elevation in nonalcoholic fatty liver diseaseJournal of Hepatology, 2014
- Inflammation as a potential link between nonalcoholic fatty liver disease and insulin resistanceJournal of Endocrinology, 2013
- The role of fructose in the pathogenesis of NAFLD and the metabolic syndromeNature Reviews Gastroenterology & Hepatology, 2010
- Nuclear Receptors, Inflammation, and Liver Disease: Insights for Cholestatic and Fatty Liver DiseasesClinical Pharmacology & Therapeutics, 2010