Radiolanthanides Device Production
Open Access
- 1 January 2015
- journal article
- research article
- Published by Scientific Research Publishing, Inc. in World Journal of Nuclear Science and Technology
- Vol. 05 (02), 111-119
- https://doi.org/10.4236/wjnst.2015.52011
Abstract
149Pm, 166Ho, 161Tb and 177Lu conjugated to chemical agents (monoclonal antibodies, polypeptide, etc.) have the appropriate decay characteristics for imaging and therapeutic studies and consequently the potential to be useful in radiotherapy and diagnosis. These carrier-free radioisotopes can be produced by neutron irradiation of a lanthanide target followed by β- decay, and a posterior radiochemical separation of the daughter radionuclide from macro-amounts of the parent target. In order to produce carrier free 149Pm, 161Tb, 166Ho and 177Lu for radiotherapy, with a radionuclide purity of more than 99.9%, a device production was developed based on separation of Nd/Pm, Gb/Tb, Dy/Ho and Yb/Lu by extraction chromatography.Keywords
This publication has 34 references indexed in Scilit:
- 6605 POSTER Phase l-ll Study of Radiopeptide 177 Lu-octreotate in Combination With Capecitabine and Temozolomide in Advanced Low-grade Neuroendocrine TumoursEuropean Journal of Cancer, 2011
- Studies on 177Lu-labeled methylene diphosphonate as potential bone-seeking radiopharmaceutical for bone pain palliationNuclear Medicine and Biology, 2011
- Comparison of the stability of Y-90-, Lu-177- and Ga-68- labeled human serum albumin microspheres (DOTA-HSAM)Nuclear Medicine and Biology, 2010
- Anti-EGFRvIII monoclonal antibody armed with 177Lu: in vivo comparison of macrocyclic and acyclic ligandsNuclear Medicine and Biology, 2010
- Comparative study on DOTA-derivatized bombesin analog labeled with 90Y and 177Lu: in vitro and in vivo evaluationNuclear Medicine and Biology, 2009
- Labeling internalizing anti-epidermal growth factor receptor variant III monoclonal antibody with 177Lu: in vitro comparison of acyclic and macrocyclic ligandsNuclear Medicine and Biology, 2009
- Antitenascin antibody 81C6 armed with 177Lu: in vivo comparison of macrocyclic and acyclic ligandsNuclear Medicine and Biology, 2007
- Radiolabeled peptide conjugates for targeting of the bombesin receptor superfamily subtypesNuclear Medicine and Biology, 2005
- Cytotoxic and genotoxic effect of the [166Dy]Dy/166Ho-EDTMP in vivo generator system in miceNuclear Medicine and Biology, 2004
- Evaluation of samarium-153 and holmium-166-EDTMP in the normal baboon modelNuclear Medicine and Biology, 1996