Interaction between Chinese medicine and digoxin: Clinical and research update
Open Access
- 7 February 2023
- journal article
- review article
- Published by Frontiers Media SA in Frontiers in Pharmacology
- Vol. 14, 1040778
- https://doi.org/10.3389/fphar.2023.1040778
Abstract
Digoxin is a widely used and long-standing cardiac drug. It has a narrow safety range, i.e., the amount leading to poisoning is only slightly higher than the amount necessary for treatment, and large individual differences in the effects of the drug have been observed. It is often used in combination with other drugs, but drug interactions have a great impact on the blood concentration of digoxin and lead to adverse reactions (ADRs), such as poisoning. Most of the reported drug interactions are with Western drugs, but interactions with traditional Chinese medicine (TCM) formulations have also been reported. However, there are many combinations of TCM formulations and Western drugs, and their efficacy is worth investigating. Therefore, it is important to understand the mutual effects between them. This paper summarizes and analyzes the TCM formulations that interact with digoxin and their mechanisms of action, in order to provide a reference for the rational and safe clinical use of digoxin.Keywords
Funding Information
- National Natural Science Foundation of China
This publication has 51 references indexed in Scilit:
- Drug Interactions with Herbal MedicinesClinical Pharmacokinetics, 2012
- Nostocyclopeptide-M1: A Potent, Nontoxic Inhibitor of the Hepatocyte Drug Transporters OATP1B3 and OATP1B1Molecular Pharmaceutics, 2011
- Effects of Shenmai Injection on serum concentration and pharmacokinetics of digoxin in dogs with heart failureJournal of Chinese Integrative Medicine, 2010
- Gauging the clinical significance of P‐glycoprotein‐mediated herb‐drug interactions: Comparative effects of St. John's wort, Echinacea, clarithromycin, and rifampin on digoxin pharmacokineticsMolecular Nutrition & Food Research, 2008
- Herbal Supplements and Therapeutic Drug Monitoring: Focus on Digoxin Immunoassays and Interactions With St. John's WortTherapeutic Drug Monitoring, 2008
- Effects of citronellal, a monoterpenoid in Zanthoxyli Fructus, on the intestinal absorption of digoxin in vitro and in vivoJournal of Pharmaceutical Sciences, 2006
- Neutralization of Free Digoxin-like Immunoreactive Components of Oriental Medicines Dan Shen and Lu-Shen-Wan by the Fab Fragment of Antidigoxin Antibody (Digibind)American Journal of Clinical Pathology, 2004
- Neutralization of Free Digoxin-like Immunoreactive Components of Oriental Medicines Dan Shen and Lu-Shen-Wan by the Fab Fragment of Antidigoxin Antibody (Digibind)American Journal of Clinical Pathology, 2004
- Effect of the traditional chinese medicines Chan Su, Lu‐Shen‐Wan, Dan Shen, and Asian Ginseng on Serum Digoxin measurement by Tina‐quant (Roche) and Synchron LX system (Beckman) digoxin immunoassaysJournal of Clinical Laboratory Analysis, 2003
- Effect of Administration of Activated Charcoal and Fibre on Absorption, Excretion and Steady State Blood Levels of Digoxin and Digitoxin. Evidence for Intestinal Secretion of the GlycosidesActa Medica Scandinavica, 1982