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DNA Damage-Induced Phosphorylation of Histone H2A at Serine 15 Is Linked to DNA End Resection

Salar Ahmad, Valérie Côté,

Abstract: The repair of DNA double-strand breaks (DSBs) occurs in chromatin, and several histone posttranslational modifications have been implicated in the process. Modifications of the histone H2A N-terminal tail have also been linked to DNA damage response, through acetylation or ubiquitination of lysine residues that regulate repair pathway choice.
Keywords: Phosphorylation / chromatin / DNA damage / H2A / Serine / acetylation / terminal / breaks / tail / ubiquitination

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