Tapentadol in the treatment of osteoarthritis: pharmacological rationale and clinical evidence
Open Access
- 1 May 2019
- journal article
- review article
- Published by Taylor & Francis Ltd in Journal of Pain Research
- Vol. ume 12, 1529-1536
- https://doi.org/10.2147/jpr.s190161
Abstract
Osteoarthritis (OA) is the most prevalent joint disease in older people worldwide. Pain owing to OA is considered one of the most frequent causes of chronic pain; however, current pharmacological approaches have some limitations in terms of efficacy and safety. Of note, descending inhibitory pain pathways are often disrupted in chronic OA pain, and pharmacotherapies targeting those pathways – eg, those that block norepinephrine reuptake may be more appropriate for managing chronic pain than pure μ-opioid receptor (MOR) agonists. Tapentadol is an analgesic molecule, which combines two synergistic mechanisms of action, MOR, and norepinephrine reuptake inhibition. This narrative review will briefly discuss the mechanisms contributing to the onset and maintenance of pain in OA patients; clinical data on the use of tapentadol in this setting will then be presented and commented.Keywords
This publication has 37 references indexed in Scilit:
- AAOS Clinical Practice Guideline: Treatment of Osteoarthritis of the Knee: Evidence-Based Guideline, 2nd EditionJournal of the American Academy of Orthopaedic Surgeons, 2013
- Effectiveness and Tolerability of Tapentadol Prolonged Release Compared With Prior Opioid Therapy for the Management of Severe, Chronic Osteoarthritis PainClinical Drug Investigation, 2013
- Mechanistic and functional differentiation of tapentadol and tramadolExpert Opinion on Pharmacotherapy, 2012
- Effectiveness and safety of tapentadol prolonged release with tapentadol immediate release on-demand for the management of severe, chronic osteoarthritis-related knee pain: results of an open-label, phase 3b studyJournal of Pain Research, 2012
- Tapentadol increases levels of noradrenaline in the rat spinal cord as measured by in vivo microdialysisNeuroscience Letters, 2012
- Neuroplasticity of sensory and sympathetic nerve fibers in a mouse model of a painful arthritic jointArthritis & Rheumatism, 2012
- Tapentadol and its two mechanisms of action: Is there a new pharmacological class of centrally‐acting analgesics on the horizon?European Journal of Pain Supplements, 2010
- Sensitization in patients with painful knee osteoarthritisPain, 2010
- Oral or transdermal opioids for osteoarthritis of the knee or hipPublished by Wiley ,2009
- Efficacy and tolerability of tapentadol immediate release and oxycodone HCl immediate release in patients awaiting primary joint replacement surgery for end-stage joint disease: A 10-day, phase III, randomized, double-blind, active- and placebo-controlled studyClinical Therapeutics, 2009