Hepatoprotective Effects of Extract of Helicteres hirsuta Lour. on Liver Fibrosis Induced by Carbon Tetrachloride in Rats
Open Access
- 20 September 2021
- journal article
- research article
- Published by MDPI AG in Applied Sciences
- Vol. 11 (18), 8758
- https://doi.org/10.3390/app11188758
Abstract
Helicteres hirsuta Lour. is a traditional Vietnamese medicine for treating chronic liver diseases such as cirrhosis and liver cancer. Many in vitro and in vivo experiments have demonstrated that the extracts and isolated compounds from H. hirsuta have diverse pharmacological activities, including antioxidant, anti-inflammatory, and anti-cancer effects. However, the hepatoprotective effects have not been reported until now. Therefore, the methanolic and ethanolic extracts of the aerial part of the H. hirsuta L. (HHM and HHE-1/1) were examined on liver fibrosis induced by carbon tetrachloride (CCl4) in rats for the first time. The results revealed that all the livers of the model group had stage F4 cirrhosis; the group that received silymarin, and HHM and HHE-1/1 had milder liver damage cirrhosis stage F1-F2 which implies that the methanolic and ethanolic extracts of H. hirsute have a definite advantage in the development of food or oral medications for hepatoprotective activity.This publication has 13 references indexed in Scilit:
- Liver fibrosis: a compilation on the biomarkers status and their significance during disease progressionFuture Science OA, 2018
- Cytotoxic triterpene saponins from the mangrove Aegiceras corniculatumNatural Product Research, 2017
- Anti-allergic effects of the ethanol extract of Syzygium formosum (Wall.) Masam leaves and its immunoregulatory mechanismsJournal of Ethnopharmacology, 2017
- Phytochemical profiles and antioxidant capacity of the crude extracts, aqueous- and saponin-enriched butanol fractions of Helicteres hirsuta Lour. leaves and stemsChemical Papers, 2017
- Protective effects of seed melon extract on CCl4-induced hepatic fibrosis in miceJournal of Ethnopharmacology, 2016
- Protective effects of extracts from Pomegranate peels and seeds on liver fibrosis induced by carbon tetrachloride in rats.BMC Complementary and Alternative Medicine, 2015
- Pathogenesis of liver cirrhosisWorld Journal of Gastroenterology, 2014
- Hepatoprotective effect of silymarinWorld Journal of Hepatology, 2014
- Abnormal Hematological Indices in CirrhosisCanadian Journal of Gastroenterology, 2009
- Prevalence of Peripheral Blood Cytopenias (Hypersplenism) in Patients With Nonalcoholic Chronic Liver DiseaseThe American Journal of Gastroenterology, 2000