PEG-400: An efficient and recyclable reaction medium for the synthesis of pyrazolo[1,5-a]pyrimidines
Open Access
- 31 December 2014
- journal article
- Published by European Journal of Chemistry in European Journal of Chemistry
- Vol. 5 (4), 676-680
- https://doi.org/10.5155/eurjchem.5.4.676-680.1110
Abstract
An efficient and convenient route is described for the synthesis of new pyrazolo [1,5-a] pyrimidine derivatives by the reaction of 4-(4’-chloro-phenylazo)-5-amino pyrazole with α,β-unsaturated carbonyl compounds (chalcones) using polyethylene glycol (PEG-400) as benign reaction medium. The advantage of this protocol includes the excellent yields, operational simplicity, short reaction times and avoidance of volatile organic solvents and expensive catalysts.Keywords
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